Regulation of Smooth Muscle Contraction by Small GTPases

被引：123
作者：
Puetz, Sandra [1 ]
Lubomirov, Lubomir T. [1 ]
Pfitzer, Gabriele [1 ]
机构：
[1] Univ Cologne, Inst Vegetat Physiol, Cologne, Germany
来源：
PHYSIOLOGY | 2009年 / 24卷 / 06期
关键词：
MYOSIN LIGHT-CHAIN; RHO-ASSOCIATED KINASE; INDUCED CA2+ SENSITIZATION; DEPENDENT PROTEIN-KINASE; NUCLEOTIDE EXCHANGE FACTOR; GTP-BINDING PROTEIN; LEUKEMIA-ASSOCIATED RHO; NITRIC-OXIDE SYNTHASE; GUINEA-PIG ILEUM; AGONIST-INDUCED CA2+-SENSITIZATION;
D O I：
10.1152/physiol.00023.2009
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Next to changes in cytosolic [Ca2+], members of the Rho subfamily of small GTPases, in particular Rho and its effector Rho kinase, also known as ROK or ROCK, emerged as key regulators of smooth muscle function in health and disease. In this review, we will focus on the regulation of the contractile machinery by Rho/ROK signaling and its interaction with PKC and cyclic nucleotide signaling. We will briefly discuss the emerging evidence that remodeling of cortical actin is necessary for contraction.
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页码：342 / 356
页数：15
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