Covalent and non-covalent binding in vanadium-protein adducts

被引：21

作者：

Ugone, Valeria ^{[1
]}

Sanna, Daniele ^{[1
]}

Ruggiu, Simone ^{[2
]}

Sciortino, Giuseppe ^{[2
,3
]}

Garribba, Eugenio ^{[2
]}

机构：

[1] Ist CNR Chim Biomol, Trav La Crucca 3, I-07100 Sassari, Italy

[2] Univ Sassari, Dipartimento Chim & Farm, Via Vienna 2, I-07100 Sassari, Italy

[3] Inst Chem Res Catalonia ICIQ, Avgda Paisos Catalans 16, Tarragona 43007, Spain

来源：

INORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 05期

关键词：

SERUM; (VO)-O-IV; DRUGS; MODES;

D O I：

10.1039/d0qi01308k

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The ESI-MS and EPR results obtained during the study of systems containing vanadium-protein adducts have been explained integrating the spectrometric and spectroscopic responses with molecular modelling simulations. The representative systems formed by the potential antibacterial drug [(VO)-O-IV (nalidixato)(2)(H2O)l with lysozyme and cytochrome c were fully characterized, interpreting the ESI-MS and EPR signals as the result of covalent and non-covalent binding. This behaviour should be considered for all metal-protein systems, and instrumental techniques - if necessary should be coupled with modelling to achieve full characterization of the types of binding.

引用

页码：1189 / 1196

页数：8

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