Synthesis and in vitro Antidiabetic Screening of Novel Dihydropyrimidine Derivatives

被引：22

作者：

Lalpara, J. N. ^{[1
]}

Vachhani, M. D. ^{[1
]}

Hadiyal, S. D. ^{[1
]}

Goswami, S. ^{[2
]}

Dubal, G. G. ^{[1
]}

机构：

[1] RK Univ, Sch Sci, Dept Chem, Rajkot 360020, Gujarat, India

[2] RK Univ, Sch Sci, Dept Microbiol, Rajkot 360020, Gujarat, India

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 57卷 / 02期

关键词：

dihydropyrimidine derivatives; oxadiazole; antidiabetic activity; aromatic aldehyde; Biginelli-type reaction;

D O I：

10.1134/S1070428021020159

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of N-substituted-6-methyl-4-{4-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxyphenyl}-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides have been synthesized by the condensation of newly synthesized {4-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxy}benzaldehyde with variously substituted acetoacetanilides and urea in the presence of ethanol. The synthesized compounds have been characterized by H-1, C-13 NMR, IR spectroscopy, and mass spectrometry. All synthesized compounds were evaluated for in vitro antidiabetic activity using the alpha-amylase inhibition assay with the 3,5-dinitrosalicylic acid (DNSA) reagent.

引用

页码：241 / 246

页数：6

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