Realizations of kinetic differential equations

被引:17
作者
Craciun, Gheorghe [1 ,2 ]
Johnston, Matthew D. [3 ]
Szederkenyi, Gabor [4 ]
Tonello, Elisa [5 ]
Toth, Janos [6 ,7 ]
Yu, Polly Y. [1 ]
机构
[1] Univ Wisconsin, Dept Math, Madison, WI 53706 USA
[2] Univ Wisconsin, Dept Biomol Chem, Madison, WI 53706 USA
[3] Lawrence Technol Univ, Dept Math & Comp Sci, Southfield, MI 48075 USA
[4] Pazmany Peter Catholic Univ, Fac Informat Technol & Bion, Budapest, Hungary
[5] Freie Univ, Dept Math & Comp Sci, Berlin, Germany
[6] Budapest Univ Technol & Econ, Dept Anal, Budapest, Hungary
[7] Eotvos Lorand Univ, Lab Chem Kinet, Budapest, Hungary
基金
美国国家科学基金会; 加拿大自然科学与工程研究理事会;
关键词
kinetic equations; reversibility; weak reversibility; mass action kinetics; reaction networks; realizations; CHEMICAL-REACTION NETWORKS; WEAKLY REVERSIBLE REALIZATIONS; MASS-ACTION; SUFFICIENT CONDITIONS; LINEAR CONJUGACY; SYSTEMS; IDENTIFIABILITY; COMPUTATION; PERSISTENCE;
D O I
10.3934/mbe.2020046
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The induced kinetic differential equations of a reaction network endowed with mass action type kinetics is a system of polynomial differential equations. The problem studied here is: Given a system of polynomial differential equations, is it possible to find a network which induces these equations; in other words: is it possible to find a kinetic realization of this system of differential equations? If yes, can we find a network with some chemically relevant properties (implying also important dynamic consequences), such as reversibility, weak reversibility, zero deficiency, detailed balancing, complex balancing, mass conservation, etc.? The constructive answers presented to a series of questions of the above type are useful when fitting differential equations to datasets, or when trying to find out the dynamic behavior of the solutions of differential equations. It turns out that some of these results can be applied when trying to solve seemingly unrelated mathematical problems, like the existence of positive solutions to algebraic equations.
引用
收藏
页码:862 / 892
页数:31
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