Reductive Cyclopropanations Catalyzed by Dinuclear Nickel Complexes

被引：75

作者：

Zhou, You-Yun ^{[1
]}

Uyeda, Christopher ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, 560 Oval Dr, W Lafayette, IN 47907 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 09期

关键词：

alkenes; carbene transfer; cyclopropanation; nickel catalysis; reductive cycloaddition; SIMMONS-SMITH CYCLOPROPANATION; ALLYLIC ALCOHOLS; ASYMMETRIC CYCLOPROPANATION; ALKYL-HALIDES; CHIRAL LIGAND; ALKENES; DISULFONAMIDE; CHLORIDE; COPPER;

D O I：

10.1002/anie.201511271

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dinuclear Ni complexes supported by naphthyridine-diimine (NDI) ligands catalyze the reductive cyclopropanation of alkenes with CH2Cl2 as the methylene source. The use of mild terminal reductants (Zn or Et2Zn) confers significant functional-group tolerance, and the catalyst accommodates structurally and electronically diverse alkenes. Mononickel catalysts bearing related Nchelates afford comparatively low cyclopropane yields (20%). These results constitute an entry into catalytic carbene transformations from oxidized methylene precursors.

引用

页码：3171 / 3175

页数：5

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