Therapeutic resistance of pancreatic cancer: Roadmap to its reversal

被引：87
作者：
Yu, Sen [1 ]
Zhang, Chunyu [1 ]
Xie, Ke-Ping [1 ]
机构：
[1] South China Univ Technol, Sch Med, Dept Gastroenterol & Hepatol, Guangzhou Peoples Hosp Affiliated 1, Guangzhou, Guangdong, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2021年 / 1875卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Pancreatic cancer; Chemotherapy; Radiotherapy; Immunotherapy; Therapeutic resistance; GROWTH-FACTOR RECEPTOR; EPITHELIAL-MESENCHYMAL TRANSITION; ANABOLIC GLUCOSE-METABOLISM; CARBOHYDRATE ANTIGEN 19-9; PHASE-III TRIAL; GEMCITABINE RESISTANCE; DUCTAL ADENOCARCINOMA; DNA-DAMAGE; UP-REGULATION; TUMOR-CELLS;
D O I：
10.1016/j.bbcan.2020.188461
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pancreatic cancer is a lethal disease with limited opportunity for resectable surgery as the first choice for cure due to its late diagnosis and early metastasis. The desmoplastic stroma and cellular genetic or epigenetic alterations of pancreatic cancer impose physical and biological barriers to effective therapies, including chemotherapy, radiotherapy, targeted therapy, and immunotherapy. Here, we review the current therapeutic options for pancreatic cancer, and underlying mechanisms and potential reversal of therapeutic resistance, a hallmark of this deadly disease.
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页数：16
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共 244 条
  • [61] PANCREOX: A Randomized Phase III Study of Fluorouracil/Leucovorin With or Without Oxaliplatin for Second-Line Advanced Pancreatic Cancer in Patients Who Have Received Gemcitabine-Based Chemotherapy
    Gill, Sharlene
    Ko, Yoo-Joung
    Cripps, Christine
    Beaudoin, Annie
    Dhesy-Thind, Sukhbinder
    Zulfiqar, Muhammad
    Zalewski, Pawel
    Do, Thuan
    Cano, Pablo
    Lam, Wendy Yin Han
    Dowden, Scot
    Grassin, Helene
    Stewart, John
    Moore, Malcolm
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (32) : 3914 - +
  • [62] MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity
    Giovannetti, Elisa
    Funel, Niccola
    Peters, Godefridus J.
    Del Chiaro, Marco
    Erozenci, Leyla A.
    Vasile, Enrico
    Leon, Leticia G.
    Pollina, Luca E.
    Groen, Annemieke
    Falcone, Alfredo
    Danesi, Romano
    Campani, Daniela
    Verheul, Henk M.
    Boggi, Ugo
    [J]. CANCER RESEARCH, 2010, 70 (11) : 4528 - 4538
  • [63] Goggins M, 1998, AM J PATHOL, V152, P1501
  • [64] Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment
    Graham, Kaitlin
    Unger, Evan
    [J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2018, 13 : 6049 - 6058
  • [65] Drug resistance in pancreatic cancer: Impact of altered energy metabolism
    Grasso, Cristoforo
    Jansen, Gerrit
    Giovannetti, Elisa
    [J]. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2017, 114 : 139 - 152
  • [66] Stroma A Double-Edged Sword in Pancreatic Cancer: A Lesson From Targeting Stroma in Pancreatic Cancer With Hedgehog Signaling Inhibitors
    Gu, Jichun
    Saiyin, Hexige
    Fu, Deliang
    Li, Ji
    [J]. PANCREAS, 2018, 47 (04) : 382 - 389
  • [67] Notch Signaling Activated by Replication Stress-Induced Expression of Midkine Drives Epithelial-Mesenchymal Transition and Chemoresistance in Pancreatic Cancer
    Guengoer, Cenap
    Zander, Hilke
    Effenberger, Katharina E.
    Vashist, Yogesh K.
    Kalinina, Tatyana
    Izbicki, Jakob R.
    Yekebas, Emre
    Bockhorn, Maximilian
    [J]. CANCER RESEARCH, 2011, 71 (14) : 5009 - 5019
  • [68] Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma
    Guillaumond, Fabienne
    Bidaut, Ghislain
    Ouaissi, Mehdi
    Servais, Stephane
    Gouirand, Victoire
    Olivares, Orianne
    Lac, Sophie
    Borge, Laurence
    Roques, Julie
    Gayet, Odile
    Pinault, Michelle
    Guimaraes, Cyrille
    Nigri, Jeremy
    Loncle, Celine
    Lavaut, Marie-Noelle
    Garcia, Stephane
    Tailleux, Anne
    Staels, Bart
    Calvo, Ezequiel
    Tomasini, Richard
    Iovanna, Juan Lucio
    Vasseur, Sophie
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (08) : 2473 - 2478
  • [69] MUC1-Mediated Metabolic Alterations Regulate Response to Radiotherapy in Pancreatic Cancer
    Gunda, Venugopal
    Souchek, Joshua
    Abrego, Jaime
    Shukla, Surendra K.
    Goode, Gennifer D.
    Vernucci, Enza
    Dasgupta, Aneesha
    Chaika, Nina V.
    King, Ryan J.
    Li, Sicong
    Wang, Shuo
    Yu, Fang
    Bessho, Tadayoshi
    Lin, Chi
    Singh, Pankaj K.
    [J]. CLINICAL CANCER RESEARCH, 2017, 23 (19) : 5881 - 5891
  • [70] Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer
    Gunderson, Andrew J.
    Kaneda, Megan M.
    Tsujikawa, Takahiro
    Nguyen, Abraham V.
    Affara, Nesrine I.
    Ruffell, Brian
    Gorjestani, Sara
    Liudahl, Shannon M.
    Truitt, Morgan
    Olson, Peter
    Kim, Grace
    Hanahan, Douglas
    Tempero, Margaret A.
    Sheppard, Brett
    Irving, Bryan
    Chang, Betty Y.
    Varner, Judith A.
    Coussens, Lisa M.
    [J]. CANCER DISCOVERY, 2016, 6 (03) : 270 - 285
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