Therapeutic resistance of pancreatic cancer: Roadmap to its reversal

被引：87
作者：
Yu, Sen [1 ]
Zhang, Chunyu [1 ]
Xie, Ke-Ping [1 ]
机构：
[1] South China Univ Technol, Sch Med, Dept Gastroenterol & Hepatol, Guangzhou Peoples Hosp Affiliated 1, Guangzhou, Guangdong, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2021年 / 1875卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Pancreatic cancer; Chemotherapy; Radiotherapy; Immunotherapy; Therapeutic resistance; GROWTH-FACTOR RECEPTOR; EPITHELIAL-MESENCHYMAL TRANSITION; ANABOLIC GLUCOSE-METABOLISM; CARBOHYDRATE ANTIGEN 19-9; PHASE-III TRIAL; GEMCITABINE RESISTANCE; DUCTAL ADENOCARCINOMA; DNA-DAMAGE; UP-REGULATION; TUMOR-CELLS;
D O I：
10.1016/j.bbcan.2020.188461
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pancreatic cancer is a lethal disease with limited opportunity for resectable surgery as the first choice for cure due to its late diagnosis and early metastasis. The desmoplastic stroma and cellular genetic or epigenetic alterations of pancreatic cancer impose physical and biological barriers to effective therapies, including chemotherapy, radiotherapy, targeted therapy, and immunotherapy. Here, we review the current therapeutic options for pancreatic cancer, and underlying mechanisms and potential reversal of therapeutic resistance, a hallmark of this deadly disease.
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页数：16
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