The 3D Genome as Moderator of Chromosomal Communication

被引：648
作者：
Dekker, Job [1 ]
Mirny, Leonid [2 ,3 ]
机构：
[1] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Program Syst Biol,Dept Biochem & Mol Pharmacol, 368 Plantat St, Worcester, MA USA
[2] MIT, Inst Med Engn & Sci, 77 Massachusetts Ave,E25-526C, Cambridge, MA 02139 USA
[3] MIT, Dept Phys, 77 Massachusetts Ave,E25-526C, Cambridge, MA 02139 USA
来源：
CELL | 2016年 / 164卷 / 06期
基金：
美国国家科学基金会;
关键词：
GENE-EXPRESSION; CHROMATIN INTERACTIONS; SPATIAL-ORGANIZATION; X-INACTIVATION; INTERPHASE CHROMOSOMES; DOSAGE COMPENSATION; ASSOCIATING DOMAINS; TOPOLOGICAL DOMAINS; REGULATORY DOMAINS; DROSOPHILA GENOME;
D O I：
10.1016/j.cell.2016.02.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Proper expression of genes requires communication with their regulatory elements that can be located elsewhere along the chromosome. The physics of chromatin fibers imposes a range of constraints on such communication. The molecular and biophysical mechanisms by which chromosomal communication is established, or prevented, have become a topic of intense study, and important roles for the spatial organization of chromosomes are being discovered. Here we present a view of the interphase 3D genome characterized by extensive physical compartmentalization and insulation on the one hand and facilitated long-range interactions on the other. We propose the existence of topological machines dedicated to set up and to exploit a 3D genome organization to both promote and censor communication along and between chromosomes.
引用
收藏
页码：1110 / 1121
页数：12
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