miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells

被引：20

作者：

Raffel, Simon ^{[1
,2
]}

Trumpp, Andreas ^{[1
,2
]}

机构：

[1] Heidelberg Inst Stem Cell Technol & Expt Med HI S, D-69120 Heidelberg, Germany

[2] Deutsch Krebsforschungszentrum DKFZ, Div Stem Cells & Canc, D-69120 Heidelberg, Germany

来源：

CANCER CELL | 2016年 / 29卷 / 02期

关键词：

ACUTE MYELOID-LEUKEMIA; IN-VIVO; ATTENUATION; EXPRESSION;

D O I：

10.1016/j.ccell.2016.01.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Leukemic stem cells (LSCs) are resistant to conventional chemotherapy and promote acute myeloid leukemia (AML) progression and recurrence. In this issue of Cancer Cell, Lechman and colleagues (2016) identify the microRNA miR/126 as a regulator of PI3K-AKT-mTOR and CDK3 signaling driving LSC self-renewal and chemotherapy resistance.

引用

页码：133 / 135

页数：4

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