Multiple gastrointestinal stromal tumors in neurofibromatosis type 1: Report of a case

被引：13

作者：

Hirashima, Kotaro ^{[1
,2
]}

Takamori, Hiroshi ^{[1
]}

Hirota, Masahiko ^{[1
]}

Tanaka, Hiroshi ^{[1
]}

Ichihara, Atsushi ^{[1
]}

Sakamoto, Yasuo ^{[1
]}

Ikuta, Yoshiaki ^{[1
]}

Karashima, Ryu-ichi ^{[1
]}

Watanabe, Masayuki ^{[1
]}

Iyama, Ken-ichi ^{[2
]}

Baba, Hideo ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Med Sci, Dept Surg Gastroenterol, Kumamoto 8608556, Japan

[2] Kumamoto Univ, Grad Sch Med Sci, Dept Surg Pathol, Kumamoto 8608556, Japan

来源：

SURGERY TODAY | 2009年 / 39卷 / 11期

关键词：

Gastrointestinal stromal tumor; Neurofibromatosis type 1; c-kit; Platelet-derived growth factor receptor alpha; Mutation; C-KIT; GENE; NF1; MUTATIONS; IMATINIB; PROTEIN; CELLS; GAP;

D O I：

10.1007/s00595-009-3963-3

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

This report presents a case of multiple gastrointestinal stromal tumors (GIST) with neurofibromatosis type 1 (NF1). A 68-year-old woman was admitted to the hospital because of a tumor close to the head of the pancreas. Imaging studies revealed submucosal tumors of the duodenum. The retroperitoneal tumor was diagnosed before surgery. Besides the main tumor in the duodenum, multiple small submucosal tumors were found in the duodenum and upper part of the jejunum during the operation. All of these tumors were resected. The histological diagnosis of all these tumors was GISTs. These tumors were immunohistochemically positive for KIT, but they demonstrated no mutation in c-kit exons 9, 11, 13, and 17, and platelet-derived growth factor receptor alpha exons 12 and 18. No recurrence occurred for a year after surgery.

引用

页码：979 / 983

页数：5

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