Action potentials of HL-1 cells recorded with silicon nanowire transistors

被引：53

作者：

Eschermann, Jan Felix ^{[1
,2
]}

Stockmann, Regina ^{[1
,2
]}

Hueske, Martin ^{[1
,2
]}

Vu, Xuan Thang ^{[1
,2
]}

Ingebrandt, Sven ^{[1
,2
,3
]}

Offenhaeusser, Andreas ^{[1
,2
]}

机构：

[1] Forschungszentrum Julich, Inst Bio & Nanosyst IBN2, D-52425 Julich, Germany

[2] Julich Aachen Res Alliance Fundamentals Future In, D-52425 Julich, Germany

[3] Univ Appl Sci Kaiserslautern, D-66482 Zweibrucken, Germany

来源：

APPLIED PHYSICS LETTERS | 2009年 / 95卷 / 08期

关键词：

cellular biophysics; elemental semiconductors; nanowires; silicon; transistors; FIELD-EFFECT TRANSISTORS; NEURONS; ARRAYS; CARDIOMYOCYTE; STIMULATION;

D O I：

10.1063/1.3194138

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Silicon nanowire (NW) transistors were fabricated in a top-down process. These devices were used to record the extracellular potential of the spontaneous activity of cardiac muscle HL-1 cells. Their signals were measured by direct dc sampling of the drain current. An improved signal-to-noise ratio compared to planar field-effect devices was observed. Furthermore the signal shape was evaluated and could be associated to different membrane currents. With these experiments, a qualitative description of the properties of the cell-NW contact was obtained and the suitability of these sensors for electrophysiological measurements in vitro was demonstrated.

引用

页数：3

共 20 条

[1] HL-1 cells: A cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte [J].