Study of the interaction between novel ruthenium(II)-polypyridyl complexes and calf thymus DNA

被引：171
|
作者：
Yang, G
Wu, JZ
Wang, L
Ji, LN
Tian, X
机构：
[1] ZHONGSHAN UNIV,DEPT CHEM,GUANGZHOU 510275,PEOPLES R CHINA
[2] LANZHOU UNIV,NATL LAB APPL ORGAN CHEM,LANZHOU 730000,PEOPLES R CHINA
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 1997年 / 66卷 / 02期
关键词：
D O I：
10.1016/S0162-0134(96)00194-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Four new complexes L(2)RuL'(2+), where L = 2,2'-bipyridine (bpy) and 1,10-phenanthroline (phen), L' are Schiff bases or phenylhydrazones derived from 4,5-diazafluoren-9-one (AFO), were prepared. They were characterized by elemental analyses, absorption, IR, and emission spectra. The binding of these complexes to calf thymus DNA has been investigated by absorption, circular dichroism spectroscopy, and viscosity measurement The experimental results show that the complexes bind to calf thymus DNA by three kinds of binding modes, respectively-electrostatic mode, nonintercalative binding mode, and intercalative binding mode. (C) 1997 Elsevier Science Inc.
引用
收藏
页码：141 / 144
页数：4
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