Circadian and Sleep Dysfunctions in Neurodegenerative Disorders-An Update

被引：39
作者：
Fifel, Karim [1 ]
Videnovic, Aleksandar [2 ,3 ,4 ]
机构：
[1] Univ Tsukuba, Int Inst Integrat Sleep Med WPI IIIS, Tsukuba, Ibaraki, Japan
[2] Massachusetts Gen Hosp, Movement Disorders Unit, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Div Sleep Med, Boston, MA 02114 USA
[4] Harvard Med Sch, Boston, MA 02115 USA
来源：
FRONTIERS IN NEUROSCIENCE | 2021年 / 14卷
基金：
美国国家卫生研究院;
关键词：
Alzheimer; Parkinson; Huntington; sleep; circadian system; EXCESSIVE DAYTIME SLEEPINESS; RESTLESS LEGS SYNDROME; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; SUPRACHIASMATIC NUCLEUS; BLOOD-PRESSURE; BEHAVIOR DISORDER; NOCTURNAL SLEEP; GENE-EXPRESSION; CLOCK GENES;
D O I：
10.3389/fnins.2020.627330
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered and multifactorial. Recent evidence suggests that sleep and circadian disturbances may influence the neurodegenerative processes as well as be their consequence. In this perspective, we provide an update of the current understanding of sleep and circadian dysregulation in Alzheimer's, Parkinson's, and Huntington's diseases.
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页数：7
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