Synthesis, characterization and cytotoxicity of platinum(II) complexes containing reduced amino acid ester Schiff bases

被引：8
作者：
Yan, Qin-Qin [1 ]
Yuan, Zhen [1 ]
Liu, Guo-Jun [1 ]
Lv, Zheng-Hua [1 ]
Fu, Bin [1 ]
Du, Jian-Long [1 ]
Li, Li-Jun [1 ]
机构：
[1] Hebei Univ, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov, Baoding 071002, Peoples R China
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2017年 / 31卷 / 06期
关键词：
cytotoxicity; DNA interaction; platinum(II) complexes; reduced amino acid ester Schiff bases; BIOLOGICAL-ACTIVITY; METAL-COMPLEXES; MANNICH-BASES; CISPLATIN;
D O I：
10.1002/aoc.3689
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Nine platinum(II) complexes containing reduced amino acid ester Schiff bases were synthesized and characterized using spectroscopy (H-1 NMR, C-13 NMR, infrared), elemental analysis and molar conductivity. The interaction of these complexes with salmon sperm DNA was investigated by means of ultraviolet and circular dichroism spectroscopies. The potential antitumor activity of all compounds was tested in vitro on HeLa and A549 tumor cell lines. Almost all the complexes exhibited better cytotoxic activity than cisplatin against these cell lines.
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页数：9
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