Is the intake of selective serotonin reuptake inhibitors associated with an increased risk of dental implant failure?

被引:41
作者
Chrcanovic, B. R. [1 ]
Kisch, J. [2 ]
Albrektsson, T. [1 ,3 ]
Wennerberg, A. [1 ]
机构
[1] Malmo Univ, Fac Odontol, Dept Prosthodont, Carl Gustafs Vag 34, SE-21421 Malmo, Sweden
[2] Ctr Dent Specialist Care, Clin Prosthodont, Malmo, Sweden
[3] Gothenburg Univ, Dept Biomat, Gothenburg, Sweden
基金
瑞典研究理事会;
关键词
dental implant; implant failure; selective serotonin reuptake inhibitors; multivariate generalized estimating equation analysis; multilevel mixed-effects parametric survival analysis; BONE-MINERAL DENSITY; SYSTEMIC FACTORS; SUPERFICIAL CHARACTERISTICS; IMPACT; ANTIDEPRESSANTS; PERIODONTITIS; EXPRESSION;
D O I
10.1016/j.ijom.2017.01.016
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The aim of this retrospective study was to investigate the association between the intake of selective serotonin reuptake inhibitors (SSRIs) and the risk of dental implant failure. Patients were included if they were taking SSRIs only and no other medication, did not present any other systemic condition or compromising habits (bruxism, smoking, snuff), and complied with the use of prophylactic antibiotics for implant surgery. The multivariate generalized estimating equation (GEE) method and multilevel mixed-effects parametric survival analysis were used to test the association between SSRI exposure (predictor variable) and the risk of implant failure (outcome variable), adjusting for several potential confounders (other variables). The total number of implants with information available and meeting the necessary eligibility criteria was 931(35 failures). These were placed in 300 patients. The implant failure rate was 12.5% for SSRI users and 3.3% for nonusers (P = 0.007). Kaplan-Meier analysis showed a statistically significant difference in the cumulative survival rate (P < 0.001). The multivariate GEE model did not show a statistically significant association between SSRI intake and implant failure (P = 0.530), nor did the multilevel model (P = 0.125). It is suggested that the intake of SSRIs may not be associated with an increased risk of dental implant failure.
引用
收藏
页码:782 / 788
页数:7
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