Bronchopulmonary dysplasia: risk prediction models for very-low-birth-weight infants

被引:24
|
作者
Valenzuela-Stutman, Daniela [1 ,11 ,20 ]
Marshall, Guillermo [1 ,11 ,20 ]
Tapia, Jose L. [1 ,11 ,20 ]
Mariani, Gonzalo [2 ,6 ]
Bancalari, Aldo [3 ,4 ,13 ]
Gonzalez, Alvaro [1 ,11 ,20 ]
Pedraza, Ana [5 ]
Colantonio, Guillermo [5 ]
Perez, Gaston [5 ]
Zapata, Jorge [5 ]
Tomas, Fortunato [5 ]
Fustinana, Carlos [6 ]
Fernandez, Silvia [6 ]
Paola Carrascal, Maria [6 ]
Galleti, Fernanda [6 ]
Tavosnaska, Jorge [7 ]
Roldan, Liliana [7 ]
Saa, Gladys [7 ]
Sabatelli, Debora [7 ]
Laura Gendra, Maria [7 ]
Teresa Sepulveda, Maria [7 ]
Fernanda Buraschi, Maria [7 ]
Basso, Graciela [7 ]
Rinaldi, Monica [8 ]
Agost, Daniel [8 ]
Solana, Claudio [9 ]
Rojas, Elio [9 ]
Nieto, Ricardo [9 ]
Meritano, Javier [9 ]
Vain, Nestor [10 ]
Cracco, Lionel [10 ]
Martinez, Edith [10 ]
Jacobi, Noemi [10 ]
San Miguel, Maria [10 ]
Toso, Paulina [11 ]
Masoli, Daniela [11 ]
Fabres, Jorge [11 ]
Estay, Alberto [11 ]
Quezada, Mariela [11 ,20 ]
Rojas, Solange [11 ,20 ]
Burgos, Jaime [12 ]
Eugenia Hubner, Maria [12 ]
Ramirez, Rodrigo [12 ]
Leon del Pedregal, Jorge [13 ]
Campos, Lilia [13 ]
Giaconi, Ximena [13 ]
Treuer, Sergio [13 ]
Standen, Jane [14 ]
Escobar, Marisol [14 ]
Sandino, Daniela [14 ]
机构
[1] Pontificia Univ Catolica Chile, Fac Med, Dept Neonatol, Santiago, Chile
[2] Inst Univ Hosp Italiano Buenos Aires, Unidad Neonatol, Potosi, Argentina
[3] Hosp Guillermo Grant Benavente, Serv Neonatol, Concepcion, Chile
[4] Univ Concepcion, Fac Med, Dept Pediat, Concepcion, Chile
[5] Clin & Maternidad Suizo Argentina, Buenos Aires, DF, Argentina
[6] Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina
[7] Hosp Juan Fernandez, Buenos Aires, DF, Argentina
[8] Hosp Lagomaggiore, Mendoza, Argentina
[9] Maternidad Sarda, Buenos Aires, DF, Argentina
[10] Sanatorio Trinidad, Buenos Aires, DF, Argentina
[11] Hosp Clin Univ Catolica Chile, Santiago, Chile
[12] Hosp Clin Univ Chile, Santiago, Chile
[13] Hosp Guillermo Grant, Concepcion, Chile
[14] Hosp Gustavo Fricke, Vina Del Mar, Chile
[15] Hosp San Jose, Santiago, Chile
[16] Hosp Dr Sotero del Rio, Santiago, Chile
[17] Dept Hosp Clin Asuncion, Asuncion, Paraguay
[18] Hosp Cayetano Heredia, Lima, Peru
[19] Serv Recien Nacidos Pereyra Rossell, Fac Med, Montevideo, Uruguay
[20] Pontificia Univ Catolica, Santiago, Chile
关键词
DISEASE; RATES; CHORIOAMNIONITIS; INTUBATION; MORBIDITY; CPAP;
D O I
10.1038/s41372-019-0430-x
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective Our objective is to develop risk prediction models for moderate/severe bronchopulmonary dysplasia (BPD) and BPD and/or death in very-low-birth-weight infants (VLBWI) at birth, 3, 7, and 14 postnatal days. Study design It is a multicenter study including 16,407 infants weighing 500-1500 g (2001-2015) from the Neocosur Network. BPD was defined as oxygen dependency at 36 weeks. Variables were selected using forward logistic regression models. Predictive values were evaluated using the ROC curve. Results In total, 2580 (15.7%) presented BPD and 6121 (37.3%) BPD/death. The AUC values for the BPD models were 0.788, 0.818, 0.827, and 0.894 respectively. For BPD/death, the AUC values were 0.860, 0.869, 0.867, and 0.906. BW and gestational age had higher contribution at birth; at later ages, the length of oxygen therapy and ventilation had the highest contribution. All AUC values were statistically significant when compared with a neutral value of 0.5 (p-value < 0.001). Conclusions We developed high predictive power models for moderate/severe BPD and BPD/death at four postnatal ages.
引用
收藏
页码:1275 / 1281
页数:7
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