Entering and Lighting Up Nuclei Using Hollow Chitosan-Gold Hybrid Nanospheres

被引：38

作者：

Hu, Yong ^{[3
]}

Chen, Qi ^{[1
,2
]}

Ding, Yin ^{[1
,2
]}

Li, Rutian ^{[4
,5
]}

jiang, Xiqun ^{[1
,2
]}

Liu, Baorui ^{[4
,5
]}

机构：

[1] Nanjing Univ, Coll Chem & Chem Engn, Lab Mesoscop Chem, Nanjing 210093, Peoples R China

[2] Nanjing Univ, Coll Chem & Chem Engn, Dept Polymer Sci & Engn, Nanjing 210093, Peoples R China

[3] Nanjing Univ, Dept Mat Sci & Engn, Natl Lab Solid State Microstruct, Nanjing 210093, Peoples R China

[4] Nanjing Med Univ, Drum Tower Hosp, Dept Oncol, Nanjing 210008, Peoples R China

[5] Nanjing Univ, Clin Canc Inst, Nanjing 210008, Peoples R China

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 36期

基金：

中国国家自然科学基金;

关键词：

BLOCK-COPOLYMER; CELLULAR UPTAKE; GENE DELIVERY; QUANTUM DOTS; NANOPARTICLES; CIS-DICHLORODIAMMINEPLATINUM(II); MICELLES; SIZE;

D O I：

10.1002/adma.200803682

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Functional hollow CS-PAA-Au-hybrid nanosp eres are prepare in aqueous solution via a one-pot route. These hollow hybrid nanospheres cannot only act as drug carriers for intracellular and intranuclear drug delivery, but also act as a contrast agent in cancer-cell imaging, and light up the nucleus. This results in a nanosphere that can execute tumor-cell. imaging and anticancer drug delivery at the same time.

引用

页码：3639 / +

页数：6

共 26 条

[1] Synthesis and characterization of gold-based mesoscopic additives for polymers [J].

Carotenuto, G ;

Nicolais, L .

POLYMER INTERNATIONAL, 2004, 53 (12) :2009-2014

[2] Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes [J].

Chithrani, B. Devika ;

Chan, Warren C. W. .

NANO LETTERS, 2007, 7 (06) :1542-1550

[3] Pollycation gene delivery systems: escape from endosomes to cytosol [J].

Cho, YW ;

Kim, JD ;

Park, K .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2003, 55 (06) :721-734

[4]

Derfus AM, 2004, NANO LETT, V4, P11, DOI 10.1021/nl0347334

[5] Polymer-monomer pairs as a reaction system for the synthesis of magnetic Fe3O4-polymer hybrid hollow nanospheres [J].

Ding, Y ;

Hu, Y ;

Jiang, XQ ;

Zhang, LY ;

Yang, CZ .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (46) :6369-6372

[6] Synthesis and magnetic properties of biocompatible hybrid hollow spheres [J].

Ding, Yin ;

Hu, Yong ;

Zhang, Leyang ;

Chen, Ying ;

Jiang, Xiqun .

BIOMACROMOLECULES, 2006, 7 (06) :1766-1772

[7] Cell-penetrating quantum dots based on multivalent and endosome-disrupting surface coatings [J].

Duan, Hongwei ;

Nie, Shuming .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (11) :3333-3338

[8] Interactions of phospholipid bilayer with chitosan: effect of molecular weight and pH [J].

Fang, N ;

Chan, V ;

Mao, HQ ;

Leong, KW .

BIOMACROMOLECULES, 2001, 2 (04) :1161-1168

[9] In vivo cancer targeting and imaging with semiconductor quantum dots [J].

Gao, XH ;

Cui, YY ;

Levenson, RM ;

Chung, LWK ;

Nie, SM .

NATURE BIOTECHNOLOGY, 2004, 22 (08) :969-976

[10] BIODEGRADABLE LONG-CIRCULATING POLYMERIC NANOSPHERES [J].

GREF, R ;

MINAMITAKE, Y ;

PERACCHIA, MT ;

TRUBETSKOY, V ;

TORCHILIN, V ;

LANGER, R .

SCIENCE, 1994, 263 (5153) :1600-1603

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