Neonatal serotonin depletion modifies development but not plasticity in rat barrel cortex

被引：13

作者：

Turlejski, K

Djavadian, RL

Kossut, M

机构：

[1] Department of Neurophysiology, Nencki Inst. of Experimental Biology, 02-093 Warsaw

来源：

NEUROREPORT | 1997年 / 8卷 / 08期

关键词：

barrel cortex; development; 5,7-dihydroxytryptamine; plasticity; rat; serotonin; vibrissectomy;

D O I：

10.1097/00001756-199705260-00007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

EFFECTS of serotonin depletion (induced by neonatal injection of 5,7-dihydroxytryptamine) upon dimensions of cortical barrels and their metabolic activation, and upon effects of neonatal vibrissectomy sparing roar C, were examined in 1-month-old rats. Dimensions of row C barrels, and of [C-14]2-deoxyglucose (2-DG) labelling in the cortex obtained after stimulation of the row C vibrissae, were measured. Serotonin depletion did not change dimensions of barrels, but reduced the extent of 2-DG labelling of cortical representation of the row C whiskers by 30%. Vibrissectomy sparing this row resulted in an expansion of the row C barrels and of 2-DG labelling in the barrel cortex that were similar in both control and serotonin-depleted rats.

引用

页码：1823 / 1828

页数：6

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