Spectrophotometric determination of tranexamic acid in dosage forms by derivatization

被引：0

作者：

Khuhawar, M. Y. ^{[1
]}

Rind, F. M. A. ^{[1
]}

Almani, K. F. ^{[1
]}

Rajpar, A. D. ^{[1
]}

机构：

[1] Shah Abdul Latif Univ, Dept Chem, Khairpur, Pakistan

来源：

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2006年 / 28卷 / 05期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tranexamic acid (TA) was determined spectrophotometrically after derivatizing with salicylaldehyde (SA) or 5, 5'-methylene-bis-salicylaldehyde (BSA) at neutral pH in aqueous-methanolic solution. The reaction conditions were optimized and the derivatives absorbed maximally at 410 nm and 412 nm for SA and BSA respectively. The Beee's law was obeyed in the range 7.8-78.6 mu g/ml tranexamic acid, with coefficient of determination of 0.9995 and 0.9998. The methods were applied for the determination of tranexamic acid in pharmaceutical preparations with coefficient of variation 0.76-0.97%.

引用

页码：435 / 438

页数：4

共 50 条

[31] Vanadophosphoric acid as a modified reagent for the spectrophotometric determination of certain cephalosporins and their dosage forms [J].

Amin, AS ;

Shama, SA .

MONATSHEFTE FUR CHEMIE, 2000, 131 (04) :313-319

[32] Simple spectrophotometric determination of cinnarizine in its dosage forms [J].

Abdine, H ;

Belal, F ;

Zoman, N .

FARMACO, 2002, 57 (04) :267-271

[33] SPECTROPHOTOMETRIC DETERMINATION OF CEPHALEXIN IN DOSAGE FORMS WITH IMIDAZOLE REAGENT [J].

ALWARTHAN, AA ;

FATTAH, SA ;

ZAHRAN, NM .

TALANTA, 1992, 39 (06) :703-707

[34] SPECTROPHOTOMETRIC DETERMINATION OF AMODIAQUINE HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORMS [J].

RAO, GR ;

RAO, YP ;

RAJU, IRK .

ANALYST, 1982, 107 (1276) :776-780

[35] Spectrophotometric and fluorimetric determination of aztreonam in bulk and dosage forms [J].

Mahgoub, H .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2003, 31 (04) :767-774

[36] Kinetic spectrophotometric determination of famotidine in commercial dosage forms [J].

Rahman, N ;

Kashif, M .

ANALYTICAL SCIENCES, 2003, 19 (06) :907-911

[37] Spectrophotometric determination of diloxanide furoate in its dosage forms [J].

Al-Ghanam, SM ;

Belal, F .

FARMACO, 2001, 56 (09) :677-681

[38] Spectrophotometric Methods for the Determination of Ketoconazole in Pharmaceutical Dosage Forms [J].

Fraihat, S. M. ;

Bahgat, K. M. .

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2014, 13 (09) :1511-1514

[39] Spectrophotometric and Spectrofluorometric Determination of Heptaminol and Mexiletine in Their Dosage Forms [J].

Anal Lett, 11 (2029)

[40] A simple spectrophotometric method for the determination of β-blockers in dosage forms [J].

Al-Ghannam, SM .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2006, 40 (01) :151-156

← 1 2 3 4 5 →