As one of active cooling method, opposing jet shows its advantages on the aerodynamic thermal reduction for hypersonic flight. To accurately predict its thermal protection features, a fluid-thermal-structural coupling strategy is adopted for a cone body with opposing jet, with a nose radius of 6 mm and jet radius of 0.6 mm. The related turbulent model and coupling method is validated by comparison of the numerical and experimental results. The interaction among flow, heat transfer, and the structural responds are gained in 60 s flight, and the influence of total pressure ratio of opposing jet (PR) is also discussed. The analysis indicates the necessary of fluid-thermal-structural coupling investigation for the details understanding of thermal protection procedure. The results show that the adoption of opposing jet can decrease the structure temperature and reduce drag obviously, and increase the stress at the tip region meanwhile, but still presents its advantage for its large enough safe factor. Besides, the adoption value of PR should be an integrated consideration of flow, heat transfer, structural response and coolant consume.