Giant cell arteritis

被引：41
作者：
Chew, S. S. L. [1 ]
Kerr, N. M. [1 ]
Danesh-Meyer, H. V. [1 ]
机构：
[1] Univ Auckland, Fac Med & Hlth Sci, Dept Ophthalmol, Auckland 1, New Zealand
来源：
JOURNAL OF CLINICAL NEUROSCIENCE | 2009年 / 16卷 / 10期
关键词：
Arteritis; Giant cell; Temporal; ERYTHROCYTE SEDIMENTATION-RATE; ISCHEMIC OPTIC NEUROPATHY; C-REACTIVE PROTEIN; PLACEBO-CONTROLLED TRIAL; TEMPORAL ARTERITIS; POLYMYALGIA-RHEUMATICA; DOUBLE-BLIND; VISUAL-LOSS; T-CELLS; DISEASE;
D O I：
10.1016/j.jocn.2009.05.002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Giant cell arteritis (GCA) is an immune-mediated vasculitis affecting individuals over 50 years of age. It is characterised by granulomatous inflammation that affects medium-sized and large arteries. The wide spectrum of clinical manifestations can be divided into those related to tissue ischemia from vascular lesions and those related to a systemic inflammatory response. The pathogenesis of these groups also appears distinct, with vascular lesion formation thought to be an adaptive immune response, and the systemic inflammatory reaction an innate immune response. Clinical suspicion of GCA must remain especially high in those with neurological or visual symptoms and if warranted, prompt treatment with high-dose corticosteroids is invaluable in halting disease progression. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1263 / 1268
页数：6
相关论文
共 108 条
[1]  
AIELLO PD, 1993, OPHTHALMOLOGY, V100, P550
[2]   Magnetic resonance imaging of large vessel vasculitis [J].
Atalay, MK ;
Bluemke, DA .
CURRENT OPINION IN RHEUMATOLOGY, 2001, 13 (01) :41-47
[3]   GIANT-CELL ARTERITIS IN ICELAND - AN EPIDEMIOLOGIC AND HISTOPATHOLOGIC ANALYSIS [J].
BALDURSSON, O ;
STEINSSON, K ;
BJORNSSON, J ;
LIE, JT .
ARTHRITIS AND RHEUMATISM, 1994, 37 (07) :1007-1012
[4]  
BARRIER J, 1981, NEW ENGL J MED, V305, P104
[5]   THE EPIDEMIOLOGY OF GIANT-CELL ARTERITIS INCLUDING TEMPORAL ARTERITIS AND POLYMYALGIA RHEUMATICA - INCIDENCES OF DIFFERENT CLINICAL PRESENTATIONS AND EYE COMPLICATIONS [J].
BENGTSSON, BA ;
MALMVALL, BE .
ARTHRITIS AND RHEUMATISM, 1981, 24 (07) :899-904
[6]  
Brack A, 1999, ARTHRITIS RHEUM, V42, P311, DOI 10.1002/1529-0131(199902)42:2<311::AID-ANR14>3.0.CO
[7]  
2-F
[8]   PLASMA VISCOSITY OR ERYTHROCYTE SEDIMENTATION-RATE IN THE DIAGNOSIS OF GIANT-CELL ARTERITIS [J].
BRITTAIN, GPH ;
MCILWAINE, GG ;
BELL, JA ;
GIBSON, JM .
BRITISH JOURNAL OF OPHTHALMOLOGY, 1991, 75 (11) :656-659
[9]   GIANT-CELL ARTERITIS (TEMPORAL ARTERITIS) PRESENTING AS FEVER OF UNDETERMINED ORIGIN [J].
CALAMIA, KT ;
HUNDER, GG .
ARTHRITIS AND RHEUMATISM, 1981, 24 (11) :1414-1418
[10]   NEUROLOGIC DISEASE IN BIOPSY-PROVEN GIANT-CELL (TEMPORAL) ARTERITIS [J].
CASELLI, RJ ;
HUNDER, GG ;
WHISNANT, JP .
NEUROLOGY, 1988, 38 (03) :352-359
12345678910