A Simple One-Pot Procedure for the Direct Homocoupling of Terminal Alkynes Promoted by Copper Nanoparticles

被引：47

作者：

Nador, Fabiana ^{[1
]}

Fortunato, Leandro ^{[1
]}

Moglie, Yanina ^{[1
]}

Vitale, Cristian ^{[1
]}

Radivoy, Gabriel ^{[1
]}

机构：

[1] Univ Nacl Sur, Inst Quim Sur, INQUISUR, CONICET,Dept Quim, RA-8000 Bahia Blanca, Buenos Aires, Argentina

来源：

SYNTHESIS-STUTTGART | 2009年 / 23期

关键词：

copper nanoparticles; alkynes; dimerizations; coupling; 1,3-diynes; STEREOCONTROLLED TOTAL-SYNTHESIS; CROSS-COUPLING REACTIONS; LIGAND-FREE; HECK REACTIONS; EFFICIENT SYNTHESIS; PALLADIUM CLUSTERS; CARBONYL-COMPOUNDS; ORGANIC-SYNTHESIS; IRON; MACROCYCLES;

D O I：

10.1055/s-0029-1217051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of different terminal alkynes with readily prepared copper(0) nanoparticles led to the formation of the corresponding symmetrical 1,4-disubstituted 1,3-diynes in good yield. No palladium, ligands, or oxidant additives were needed, For aliphatic terminal alkynes, the use of sodium carbonate as base markedly improved the reaction rate and allowed the use of a substoichiometric amount of the copper nanoparticles.

引用

页码：4027 / 4031

页数：5

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