Chemical transformations of selenium in living organisms. Improved forms of selenium for cancer prevention

被引：96
作者：
Ganther, HE
Lawrence, JR
机构：
[1] Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706
来源：
TETRAHEDRON | 1997年 / 53卷 / 36期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0040-4020(97)00561-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Compounds having cancer-preventing activity are developed during the metabolism of selenium in plants and animals. Monomethylated forms of selenium appear to be one class of chemopreventive metabolites. Synthetic organoselenium compounds have been used to explore determinants of activity and differentiation from other biological effects of selenium. Triphenyl selenonium chloride, a new type of chemopreventive selenium compound has been synthesized in radioactive form for use as a tracer to facilitate studies of its mode of action. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：12299 / 12310
页数：12
相关论文
共 51 条
[31]  
KEEN JH, 1976, J BIOL CHEM, V251, P6183
[32]   DISSOCIATION OF THE GENOTOXIC AND GROWTH-INHIBITORY EFFECTS OF SELENIUM [J].
LU, JX ;
JIANG, C ;
KAECK, M ;
GANTHER, H ;
VADHANAVIKIT, S ;
IP, C ;
THOMPSON, H .
BIOCHEMICAL PHARMACOLOGY, 1995, 50 (02) :213-219
[33]   CELLULAR AND METABOLIC EFFECTS OF TRIPHENYLSELENONIUM CHLORIDE IN A MAMMARY CELL-CULTURE MODEL [J].
LU, JX ;
JIANG, C ;
KAECK, M ;
GANTHER, H ;
IP, C ;
THOMPSON, H .
CARCINOGENESIS, 1995, 16 (03) :513-517
[34]   SYNTHETIC SELENOORGANIC COMPOUND WITH GLUTATHIONE PEROXIDASE-LIKE ACTIVITY IN THE CHICK [J].
MERCURIO, SD ;
COMBS, GF .
BIOCHEMICAL PHARMACOLOGY, 1986, 35 (24) :4505-4509
[35]  
MOZIER NM, 1988, J BIOL CHEM, V263, P4527
[36]   BIOSYNTHESIS AND URINARY-EXCRETION OF METHYL SULFONIUM DERIVATIVES OF THE SULFUR MUSTARD ANALOG, 2-CHLOROETHYL ETHYL SULFIDE, AND OTHER THIOETHERS [J].
MOZIER, NM ;
HOFFMAN, JL .
FASEB JOURNAL, 1990, 4 (15) :3329-3333
[37]   PHOTOLYSIS OF A CHARGE-TRANSFER COMPLEX - TRIPHENYLSULFONIUM IODIDE [J].
NICKOL, SL ;
KAMPMEIE.JA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (06) :1908-1915
[38]  
OLSON OE, 1987, J AM COLL TOXICOL, V5, P45
[39]  
REDDY BS, 1987, CANCER RES, V47, P5901
[40]   SELENIUM - BIOCHEMICAL ROLE AS A COMPONENT OF GLUTATHIONE PEROXIDASE [J].
ROTRUCK, JT ;
POPE, AL ;
GANTHER, HE ;
SWANSON, AB ;
HAFEMAN, DG ;
HOEKSTRA, WG .
SCIENCE, 1973, 179 (4073) :588-590
123456