Bubble-Propelled Janus Gallium/Zinc Micromotors for the Active Treatment of Bacterial Infections

被引：178
作者：
Lin, Zhihua [1 ]
Gao, Changyong [1 ]
Wang, Daolin [1 ]
He, Qiang [1 ]
机构：
[1] Harbin Inst Technol, Key Lab Microsyst & Microstruct Mfg, 92 West Dazhi St, Harbin 150080, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 16期
基金：
中国国家自然科学基金;
关键词：
active treatment; antibacterial agents; gallium; micromotors; self-propulsion; HELICOBACTER-PYLORI; DRIVEN;
D O I：
10.1002/anie.202016260
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a bubble-propelled Janus gallium/zinc (Ga/Zn) micromotor with good biocompatibility and biodegradability for active target treatment of bacteria. The Janus Ga/Zn micromotors are fabricated by asymmetrically coating liquid metal Ga on Zn microparticles and display self-propulsion in simulated gastroenteric acid (pH 0.5) at a speed of up to 383 mu m s(-1), propelled by hydrogen bubbles generated by the zinc-acid reaction. This motion of Ga/Zn micromotors is enhanced by the Ga-Zn galvanic effect. The Ga-III cations produced from the degradation of Ga/Zn micromotors serve as a built-in antibiotic agent. The movement improves the diffusion of Ga-III and results in a significant increase of the antibacterial efficiency against H. pylori, compared with passive Ga microparticles. Such Ga/Zn micromotors combine the self-propulsion, good biocompatibility and biodegradability, and Ga-based antibacterial properties, providing a proof of concept for the active treatment of bacterial infections.
引用
收藏
页码：8750 / 8754
页数：5
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