Silica-supported sodium sulfonate with ionic liquid: A neutral catalyst system for Michael reactions of indoles in water

被引：87

作者：

Gu, Yanlong ^{[1
]}

Ogawa, Chikako ^{[1
]}

Kobayashi, Shu ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, HFRE Div, ERATO,Japan Sci & Technol Agcy,Bunkyo Ku, Tokyo 1130033, Japan

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 02期

关键词：

D O I：

10.1021/ol062446b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A neutral catalytic system for Michael reactions of indoles has been developed by combining silica-supported benzenesulfonic acid sodium salt with hydrophobic ionic liquid in water. An efficient hydrophobic environment could be created on the surface of the silica-sodium material under the conditions. Various indole derivatives and alpha,beta-unsaturated carbonyl compounds including some acid-labile substrates were successfully applied to this system with water as the sole solvent to afford the desired Michael adducts in high yields.

引用

页码：175 / 178

页数：4

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