CLAVULANIC ACID AND CEPHAMICIN C: A PERSPECTIVE OF THE BIOSYNTHESIS, ISOLATION AND ACTION MECHANISM

被引：3

作者：

de Oliveira, Jaine H. H. Luiz ^{[1
]}

Granato, Ana Claudia ^{[1
]}

Hirata, Daniela B. ^{[1
]}

Hokka, Carlos O. ^{[1
]}

Barboza, Marlei ^{[1
]}

Trsic, Milan ^{[2
]}

机构：

[1] Univ Fed Sao Carlos, Dept Engn Quim, BR-13565905 Sao Carlos, SP, Brazil

[2] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil

来源：

QUIMICA NOVA | 2009年 / 32卷 / 08期

关键词：

beta-lactam antibiotics; clavulanic acid; cephamycin C; BETA-LACTAM ANTIBIOTICS; CELL-FREE-EXTRACTS; STREPTOMYCES-CLAVULIGERUS; ESCHERICHIA-COLI; PURIFICATION; ORNITHINE; ARGININE; ENZYME; INACTIVATION; CEPHAMYCINS;

D O I：

10.1590/S0100-40422009000800028

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

CLAVULANIC ACID AND CEPHAMICIN C: A PERSPECTIVE OF THE BIOSYNTHESIS, ISOLATION AND ACTION MECHANISM. The present article reviews different aspects of the chemistry of two widely used beta-lactam antibiotics Clavulanic Acid and Cephamycin C. The article discusses important details of the biosynthesis of these compounds, their action mechanism and, principally, the methods employed in their isolation and purification, in accordance with the available literature. Despite the large quantity of available articles and patents concerning beta-lactam antibiotics, those which describe the isolation and purification of Clavulanic Acid and Cephamycin C are rare. Overall, the intention of this article is to discuss the up-to-date scientific research related to the compounds under review.

引用

页码：2142 / 2150

页数：9

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