Vav and Rac Activation in B Cell Antigen Receptor Endocytosis Involves Vav Recruitment to the Adapter Protein LAB

被引：28

作者：

Malhotra, Shikha ^{[1
,2
]}

Kovats, Susan ^{[3
]}

Zhang, Weiguo ^{[4
]}

Coggeshall, K. Mark ^{[1
,2
]}

机构：

[1] Univ Oklahoma, Immunobiol & Canc Program, Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Dept Cell Biol, Oklahoma City, OK 73104 USA

[3] Oklahoma Med Res Fdn, Arthritis & Immunol Program, Oklahoma City, OK 73104 USA

[4] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2009年 / 284卷 / 52期

关键词：

NUCLEOTIDE EXCHANGE FACTOR; INOSITOL PHOSPHATASE SHIP; FC-GAMMA-RIIB; T-CELLS; TYROSINE PHOSPHORYLATION; DIFFERENTIAL REGULATION; SIGNALING PATHWAYS; SH2; DOMAIN; GTPASES; INTERNALIZATION;

D O I：

10.1074/jbc.M109.040089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The signal transduction events supporting B cell antigen receptor (BCR) endocytosis are not well understood. We have identified a pathway supporting BCR internalization that begins with tyrosine phosphorylation of the adapter protein LAB. Phosphorylated LAB recruits a complex of Grb2-dynamin and the guanine nucleotide exchange factor Vav. Vav is required for activation of the small GTPases Rac1 and Rac2. All these proteins contribute to (and dynamin, Vav, and Rac1/2 are required for) BCR endocytosis and presentation of antigen to T cells. This is the first description of a sequential signal transduction pathway from BCR to internalization and antigen presentation.

引用

页码：36202 / 36212

页数：11

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