Nanoparticle-Based Delivery to Treat Spinal Cord Injury-a Mini-review

被引：31

作者：

Chakraborty, Atanu ^{[1
]}

Ciciriello, Andrew J. ^{[2
,3
]}

Dumont, Courtney M. ^{[2
,3
]}

Pearson, Ryan M. ^{[1
,4
,5
]}

机构：

[1] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, 20 N Pine St, Baltimore, MD 21201 USA

[2] Univ Miami, Dept Biomed Engn, 1251 Mem Dr, Coral Gables, FL 33156 USA

[3] Univ Miami, BioNIUM, Biomed Nanotechnol Inst, 1951 NW Seventh Ave,Suite 475, Miami, FL 33136 USA

[4] Univ Maryland, Sch Med, Dept Mol Microbiol & Immunol, 685 W Baltimore St, Baltimore, MD 21201 USA

[5] Univ Maryland, Sch Med, Marlene & Stewart Greenebaum Comprehens Canc Ctr, 22 S Greene St, Baltimore, MD 21201 USA

来源：

AAPS PHARMSCITECH | 2021年 / 22卷 / 03期

关键词：

nanoparticles; spinal cord injury; inflammation; tissue engineering; drug delivery;

D O I：

10.1208/s12249-021-01975-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

There is an increasing need to develop improved and non-invasive strategies to treat spinal cord injury (SCI). Nanoparticles (NPs) are an enabling technology to improve drug delivery, modulate inflammatory responses, and restore functional responses following SCI. However, the complex pathophysiology associated with SCI presents several distinct challenges that must be overcome for sufficient NP drug delivery to the spinal cord. The objective of this mini-review is to highlight the physiological challenges and cell types available for modulation and discuss several promising advancements using NPs to improve SCI treatment. We will focus our discussion on recent innovative approaches in NP drug delivery and how the implementation of multifactorial approaches to address the proinflammatory and complex immune dysfunction in SCI offers significant potential to improve outcomes in SCI.

引用

页数：9

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