Genes Involved in the Development and Physiology of Both the Peripheral and Central Auditory Systems

被引:25
作者
Michalski, Nicolas [1 ,2 ,3 ]
Petit, Christine [1 ,2 ,3 ,4 ,5 ]
机构
[1] Inst Pasteur, Unite Genet & Physiol Audit, F-75015 Paris, France
[2] INSERM, UMRS 1120, F-75015 Paris, France
[3] Sorbonne Univ, F-75005 Paris, France
[4] Inst Vis, Syndrome Usher & Autres Atteintes Retino Cochleai, F-75012 Paris, France
[5] Coll France, F-75005 Paris, France
来源
ANNUAL REVIEW OF NEUROSCIENCE, VOL 42 | 2019年 / 42卷
基金
欧洲研究理事会;
关键词
hair cell; cochlea; auditory hindbrain; auditory cortex; evolution; gene regulatory networks; HAIR-CELL-DIFFERENTIATION; ANKLE-LINK COMPLEX; INNER-EAR; BRAIN-STEM; VESTIBULAR FUNCTION; SPIRAL GANGLION; RIBBON SYNAPSE; HEARING-LOSS; MOUSE MODEL; DEAFNESS;
D O I
10.1146/annurev-neuro-070918-050428
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The genetic approach, based on the study of inherited forms of deafness, has proven to be particularly effective for deciphering the molecular mechanisms underlying the development of the peripheral auditory system, the cochlea and its afferent auditory neurons, and how this system extracts the physical parameters of sound. Although this genetic dissection has provided little information about the central auditory system, scattered data suggest that some genes may have a critical role in both the peripheral and central auditory systems. Here, we review the genes controlling the development and function of the peripheral and central auditory systems, focusing on those with demonstrated intrinsic roles in both systems and highlighting the current underappreciation of these genes. Their encoded products are diverse, from transcription factors to ion channels, as are their roles in the central auditory system, mostly evaluated in brainstem nuclei. We examine the ontogenetic and evolutionary mechanisms that may underlie their expression at different sites.
引用
收藏
页码:67 / 86
页数:20
相关论文
共 126 条
  • [21] Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human
    Charizopoulou, Nikoletta
    Lelli, Andrea
    Schraders, Margit
    Ray, Kausik
    Hildebrand, Michael S.
    Ramesh, Arabandi
    Srisailapathy, C. R. Srikumari
    Oostrik, Jaap
    Admiraal, Ronald J. C.
    Neely, Harold R.
    Latoche, Joseph R.
    Smith, Richard J. H.
    Northup, John K.
    Kremer, Hannie
    Holt, Jeffrey R.
    Noben-Trauth, Konrad
    [J]. NATURE COMMUNICATIONS, 2011, 2
  • [22] DEVELOPMENTAL DEFECTS OF THE EAR, CRANIAL NERVES AND HINDBRAIN RESULTING FROM TARGETED DISRUPTION OF THE MOUSE HOMEOBOX GENE HOX-1.6
    CHISAKA, O
    MUSCI, TS
    CAPECCHI, MR
    [J]. NATURE, 1992, 355 (6360) : 516 - 520
  • [23] Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear
    Chonko, Kurt T.
    Jahan, Israt
    Stone, Jennifer
    Wright, Margaret C.
    Fujiyama, Tomoyuki
    Hoshino, Mikio
    Fritzsch, Bernd
    Maricich, Stephen M.
    [J]. DEVELOPMENTAL BIOLOGY, 2013, 381 (02) : 401 - 410
  • [24] Molecular mechanisms underlying inner ear patterning defects in kreisler mutants
    Choo, D
    Ward, J
    Reece, A
    Dou, HW
    Lin, ZS
    Greinwald, J
    [J]. DEVELOPMENTAL BIOLOGY, 2006, 289 (02) : 308 - 317
  • [25] Inner ear manifestations in CHARGE: Abnormalities, treatments, animal models, and progress toward treatments in auditory and vestibular structures
    Choo, Daniel I.
    Tawfik, Kareem O.
    Martin, Donna M.
    Raphael, Yehoash
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS, 2017, 175 (04) : 439 - 449
  • [26] THE MOUSE SEGMENTATION GENE KR ENCODES A NOVEL BASIC DOMAIN LEUCINE-ZIPPER TRANSCRIPTION FACTOR
    CORDES, SP
    BARSH, GS
    [J]. CELL, 1994, 79 (06) : 1025 - 1034
  • [27] AXON GUIDANCE IN THE AUDITORY SYSTEM: MULTIPLE FUNCTIONS OF EPH RECEPTORS
    Cramer, K. S.
    Gabriele, M. L.
    [J]. NEUROSCIENCE, 2014, 277 : 152 - 162
  • [28] Transcription factor evolution in eukaryotes and the assembly of the regulatory toolkit in multicellular lineages
    de Mendoza, Alex
    Sebe-Pedros, Arnau
    Sestak, Martin Sebastijan
    Matejcic, Marija
    Torruella, Guifre
    Domazet-Loso, Tomislav
    Ruiz-Trillo, Inaki
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (50) : E4858 - E4866
  • [29] Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes
    Delmaghani, Sedigheh
    Defourny, Jean
    Aghaie, Asadollah
    Beurg, Maryline
    Dulon, Didier
    Thelen, Nicolas
    Perfettini, Isabelle
    Zelles, Tibor
    Aller, Mate
    Meyer, Anais
    Emptoz, Alice
    Giraudet, Fabrice
    Leibovici, Michel
    Dartevelle, Sylvie
    Soubigou, Guillaume
    Thiry, Marc
    Vizi, E. Sylvester
    Safieddine, Saaid
    Hardelin, Jean-Pierre
    Avan, Paul
    Petit, Christine
    [J]. CELL, 2015, 163 (04) : 894 - 906
  • [30] Tunicates and not cephalochordates are the closest living relatives of vertebrates
    Delsuc, F
    Brinkmann, H
    Chourrout, D
    Philippe, H
    [J]. NATURE, 2006, 439 (7079) : 965 - 968