The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases

被引：236

作者：

Abella, Vanessa ^{[1
,2
]}

Scotece, Morena ^{[1
]}

Conde, Javier ^{[1
]}

Gomez, Rodolfo ^{[1
]}

Lois, Ana ^{[1
]}

Pino, Jesus ^{[3
]}

Gomez-Reino, Juan J. ^{[1
]}

Lago, Francisca ^{[4
]}

Mobasheri, Ali ^{[5
,6
,7
,8
]}

Gualillo, Oreste ^{[1
]}

机构：

[1] Univ Santiago, NEIRID Lab Neuroendocrine Interact Rheumatol & In, SERGAS Serv Galego Saude, Res Lab 9,Inst Med Res IDIS,Clin Hosp, Trav Choupana Sn, Santiago De Compostela 15706, Spain

[2] Univ A Coruna, Fac Ciencias, Dept Biol Celular & Mol, Campus De A Coruna, Spain

[3] Univ Santiago, Clin Hosp, Div Orthopaed Surg & Traumatol, SERGAS, Santiago De Compostela, Spain

[4] Univ Santiago, Mol & Cellular Cardiol Lab, Inst Med Res IDIS, SERGAS Serv Galego Saude,Res Lab 7,Clin Hosp, Santiago De Compostela, Spain

[5] Univ Surrey, D BOARD European Consortium Biomarker Discovery, Sch Vet Med, Dept Vet Preclin Sci,Fac Hlth & Med Sci, Guildford GU2 5XH, Surrey, England

[6] Univ Nottingham, Queens Med Ctr, Arthrit Res UK Ctr Sport Exercise & Osteoarthrit, Arthrit Res UK Pain Ctr,Med Res Council, Nottingham NG7 2RD, England

[7] Univ Nottingham, Arthrit Res UK Ctr Musculoskeletal Ageing Res, Nottingham NG7 2RD, England

[8] King Abdulaziz Univ, Fac Appl Med Sci, KFMRC, CEGMR, Jeddah 21413, Saudi Arabia

来源：

BIOMARKERS | 2015年 / 20卷 / 08期

关键词：

kidney diseases; Adipokines; immunity; rheumatic diseases; adipose tissue; GELATINASE-ASSOCIATED LIPOCALIN; ADAPTIVE IMMUNE-RESPONSES; INSULIN-RESISTANCE; LUPUS NEPHRITIS; IN-VITRO; EXPRESSION; IRON; PROTEIN; RECEPTOR; MOUSE;

D O I：

10.3109/1354750X.2015.1123354

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to bind small substances, such as steroids and lipopolysaccharides, and has been reported to have roles in the induction of apoptosis in hematopoietic cells, transport of fatty acids and iron, modulation of inflammation, and metabolic homeostasis. Recently, LCN2 has emerged as a useful biomarker and rheumatic diseases. This review provides an overview of LCN2 in inflammation, immunity, and metabolism.

引用

页码：565 / 571

页数：7

共 72 条

[1] Lipocalin-2 regulates the inflammatory response during ischemia and reperfusion of the transplanted heart
Aigner, F.
Maier, H. T.
Schwelberger, H. G.
Wallnoefer, E. A.
Amberger, A.
Obrist, P.
Berger, T.
Mak, T. W.
Maglione, M.
Margreiter, R.
Schneeberger, S.
Troppmair, J.
[J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2007, 7 (04) : 779 - 788
[2] Bao GH, 2010, NAT CHEM BIOL, V6, P602, DOI [10.1038/NCHEMBIO.402, 10.1038/nchembio.402]
[3] CLONING AND EXPRESSION OF HUMAN NEUTROPHIL LIPOCALIN CDNA DERIVED FROM BONE-MARROW AND OVARIAN-CANCER CELLS
BARTSCH, S
TSCHESCHE, H
[J]. FEBS LETTERS, 1995, 357 (03) : 255 - 259
[4] Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis
Berard, Jennifer L.
Zarruk, Juan G.
Arbour, Nathalie
Prat, Alexandre
Yong, V. Wee
Jacques, Francois H.
Akira, Shizuo
David, Samuel
[J]. GLIA, 2012, 60 (07) : 1145 - 1159
[5] Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage
Bolignano, Davide
Donato, Valentina
Coppolino, Giuseppe
Campo, Susanna
Buemi, Antoine
Lacquaniti, Antonio
Buemi, Michele
[J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 2008, 52 (03) : 595 - 605
[6] Neutrophil gelatinase-associated lipocalin, a siderophore-binding eukaryotic protein
Borregaard, Niels
Cowland, Jack B.
[J]. BIOMETALS, 2006, 19 (02) : 211 - 215
[7] Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis
Brunner, Hermine I.
Bennett, Michael R.
Mina, Rina
Suzuki, Michiko
Petri, Michelle
Kiani, Adnan N.
Pendl, Joshua
Witte, David
Ying, Jun
Rovin, Brad H.
Devarajan, Prasad
[J]. ARTHRITIS AND RHEUMATISM, 2012, 64 (08): : 2687 - 2697
[8] The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer
Chakraborty, Subhankar
Kaur, Sukhwinder
Guha, Sushovan
Batra, Surinder K.
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2012, 1826 (01): : 129 - 169
[9] Fecal Lipocalin 2, a Sensitive and Broadly Dynamic Non-Invasive Biomarker for Intestinal Inflammation
Chassaing, Benoit
Srinivasan, Gayathri
Delgado, Maria A.
Young, Andrew N.
Gewirtz, Andrew T.
Vijay-Kumar, Matam
[J]. PLOS ONE, 2012, 7 (09):
[10] Chu ST, 1998, J PEPT RES, V52, P390

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