A bistable genetic switch which does not require high co-operativity at the promoter: a two-timescale model for the PU.1-GATA-1 interaction

被引：18

作者：

Bokes, Pavol ^{[1
]}

King, John R. ^{[1
]}

Loose, Matthew ^{[2
]}

机构：

[1] Univ Nottingham, Ctr Math Med & Biol, Sch Math Sci, Nottingham NG7 2RD, England

[2] Univ Nottingham, Inst Genet, Queens Med Ctr, Nottingham NG7 2UH, England

来源：

MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA | 2009年 / 26卷 / 02期

关键词：

systems biology; hematopoiesis; transcription factor; HEMATOPOIETIC STEM-CELLS; LINEAGE SPECIFICATION; TRANSCRIPTION FACTORS; ESCHERICHIA-COLI; GATA-1; DIFFERENTIATION; PU.1; PROGENITOR; COMMITMENT;

D O I：

10.1093/imammb/dqn026

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The transcription factors PU.1 and GATA-1 antagonize each other in common myeloid progenitors and their relative abundance is thought to decide whether the cell follows the erythrocyte/megakaryocyte lineage or the granulocyte/macrophage lineage. We propose a kinetic model for the PU.1-GATA-1 interaction, analyse its phase space and interpret the results of our analysis. The conclusions have broader implications for the modelling of cell-fate selection.

引用

页码：117 / 132

页数：16

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