Calcium-dependent inactivation of neuronal calcium channels

被引:162
作者
Budde, T [1 ]
Meuth, S [1 ]
Pape, HC [1 ]
机构
[1] Univ Magdeburg, Inst Physiol, D-39120 Magdeburg, Germany
关键词
D O I
10.1038/nrn959
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Calcium ions are ubiquitous intracellular mediators of numerous cellular processes. One of the main mechanisms of Ca2+ entry into the cell involves the opening of Ca2+ channels in the plasma membrane. To effectively control Ca2+ signalling, Ca2+ channels inactivate rapidly by a mechanism that depends on an elevation of intracellular Ca2+ within tens of nanometres of the channel pore. A structural understanding of this mechanism will provide a framework for understanding the regulation of Ca2+ entry and accumulation in neurons. Recent physiological, biochemical and molecular studies have yielded new insights into the regulation of neuronal Ca2+ channels.
引用
收藏
页码:873 / 883
页数:11
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