Calcium-dependent inactivation of neuronal calcium channels

被引：161

作者：

Budde, T ^{[1
]}

Meuth, S ^{[1
]}

Pape, HC ^{[1
]}

机构：

[1] Univ Magdeburg, Inst Physiol, D-39120 Magdeburg, Germany

来源：

NATURE REVIEWS NEUROSCIENCE | 2002年 / 3卷 / 11期

关键词：

D O I：

10.1038/nrn959

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Calcium ions are ubiquitous intracellular mediators of numerous cellular processes. One of the main mechanisms of Ca2+ entry into the cell involves the opening of Ca2+ channels in the plasma membrane. To effectively control Ca2+ signalling, Ca2+ channels inactivate rapidly by a mechanism that depends on an elevation of intracellular Ca2+ within tens of nanometres of the channel pore. A structural understanding of this mechanism will provide a framework for understanding the regulation of Ca2+ entry and accumulation in neurons. Recent physiological, biochemical and molecular studies have yielded new insights into the regulation of neuronal Ca2+ channels.

引用

页码：873 / 883

页数：11

共 104 条

[91]

THEURKAUF WE, 1982, J BIOL CHEM, V257, P3284

[92] INACTIVATION OF CA CONDUCTANCE DEPENDENT ON ENTRY OF CA IONS IN MOLLUSCAN NEURONS [J].

TILLOTSON, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (03) :1497-1500

[93] ACCELERATION OF ACTIVATION AND INACTIVATION BY THE BETA SUBUNIT OF THE SKELETAL-MUSCLE CALCIUM-CHANNEL [J].

VARADI, G ;

LORY, P ;

SCHULTZ, D ;

VARADI, M ;

SCHWARTZ, A .

NATURE, 1991, 352 (6331) :159-162

[94] Mechanism of Ca-2+-dependent inactivation of L-type Ca2+ channels in GH(3) cells: Direct evidence against dephosphorylation by calcineurin [J].

Victor, RG ;

Rusnak, F ;

Sikkink, R ;

Marban, E ;

ORourke, B .

JOURNAL OF MEMBRANE BIOLOGY, 1997, 156 (01) :53-61

[95] SUBUNIT IDENTIFICATION AND RECONSTITUTION OF THE N-TYPE CA2+ CHANNEL COMPLEX PURIFIED FROM BRAIN [J].

WITCHER, DR ;

DEWAARD, M ;

SAKAMOTO, J ;

FRANZINIARMSTRONG, C ;

PRAGNELL, M ;

KAHL, SD ;

CAMPBELL, KP .

SCIENCE, 1993, 261 (5120) :486-489

[96] RETRACTED: Calmodulin kinase and a calmodulin-binding 'IQ' domain facilitate L-type Ca2+ current in rabbit ventricular myocytes by a common mechanism (Retracted article. See vol. 593, pg. 2249, 2015) [J].

Wu, YJ ;

Dzhura, I ;

Colbran, RJ ;

Anderson, ME .

JOURNAL OF PHYSIOLOGY-LONDON, 2001, 535 (03) :679-687

[97] DUAL REGULATION OF CA2+/CALMODULIN-DEPENDENT KINASE-II ACTIVITY BY MEMBRANE VOLTAGE AND BY CALCIUM INFLUX [J].

XIAO, RP ;

CHENG, HP ;

LEDERER, WJ ;

SUZUKI, T ;

LAKATTA, EG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (20) :9659-9663

[98] CALCIUM-SENSITIVE INACTIVATION IN THE GATING OF SINGLE CALCIUM CHANNELS [J].

YUE, DT ;

BACKX, PH ;

IMREDY, JP .

SCIENCE, 1990, 250 (4988) :1735-1738

[99]

Zeilhofer HU, 2000, NEUROSCIENCE, V95, P235

[100] Feedback inhibition of Ca2+ channels by Ca2+ depends on a short sequence of the C terminus that does not include the Ca2+-binding function of a motif with similarity to Ca2+-binding domains [J].

Zhou, JM ;

Olcese, R ;

Qin, N ;

Noceti, F ;

Birnbaumer, L ;

Stefani, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) :2301-2305

← 2 3 4 5 6 7 8 9 10 11 →