Effects of oral glucosamine sulphate on serum glucose and insulin during an oral glucose tolerance test of subjects with osteoarthritis

被引:33
作者
Biggee, B. A.
Blinn, C. M.
Nuite, M.
Silbert, J. E.
McAlindon, T. E.
机构
[1] Edith Nourse Rogers Mem Vet Adm Hosp, Connect Tissue Res Lab, Bedford, MA 01730 USA
[2] Tufts Univ, New England Med Ctr, Div Rheumatol, Boston, MA 02111 USA
[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Rheumatol Immunol Allergy, Boston, MA 02115 USA
关键词
D O I
10.1136/ard.2006.058222
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and objective: Glucosamine is suggested to affect glucose transport and insulin resistance. The effects of oral glucosamine on serum glucose and insulin levels at the initiation and throughout the duration of a 3-h oral glucose tolerance test were examined. Methods: Sera from 16 patients with osteoarthritis, but with no other diagnosed medical condition who had fasted overnight, were obtained every 15-30 min during the 3 h of continued fasting and during the 3 h after ingestion of 75 g of glucose with or without ingestion of 1500 mg of glucosamine sulphate. Glucose was analysed by high-performance liquid chromatography using a Metrohm-Peak 817 Bioscan, and the area under the curve (AUC) for glucose was calculated. Insulin was measured by radioimmunoassay every 30 min for 2 h. Results: Three participants who were found to have previously undiagnosed abnormalities of glucose tolerance demonstrated significant (p = 0.04) incremental elevations in glucose levels after ingestion of glucosamine sulphate. The other 13 participants also had mean incremental elevations that were not significant (p = 0.20). Glucosamine sulphate ingestion had no effect on insulin levels. Conclusion: The results suggest that glucosamine ingestion may affect glucose levels and consequent glucose uptake in patients who have untreated diabetes or glucose intolerance.
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收藏
页码:260 / 262
页数:3
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