Automated radiosynthesis of [11C]L-deprenyl-D2 and [11C]D-deprenyl using a commercial platform

被引：10

作者：

Buccino, Pablo ^{[1
]}

Kreimerman, Ingrid ^{[1
]}

Zirbesegger, Kevin ^{[1
]}

Porcal, Williams ^{[1
,2
]}

Savio, Eduardo ^{[1
,3
]}

Engler, Henry ^{[1
]}

机构：

[1] Ctr Uruguayo Imagenol Mol CUDIM, Ricaldoni 2010, Montevideo 11600, Uruguay

[2] Univ Republica, Fac Quim, Dept Quim Organ, Gral Flores 2124, Montevideo 11800, Uruguay

[3] Univ Republica, Fac Quim, Catedra Radioquim, Gral Flores 2124, Montevideo 11800, Uruguay

来源：

APPLIED RADIATION AND ISOTOPES | 2016年 / 110卷

关键词：

C-11]L-deprenyl-D-2; C-11]D-deprenyl; Automated synthesis; PET chemistry; POSITRON-EMISSION-TOMOGRAPHY; MONOAMINE-OXIDASE; L-DEPRENYL; ASTROCYTOSIS; C-11; PET; DISEASE; MULTITRACER;

D O I：

10.1016/j.apradiso.2015.12.051

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two C-11-labelled PET tracers, (R)-N-[C-11]methyl-N-(3,3-dideuteropropargyl)-1-phenylpropan-2-amine ([C-11]L-deprenyl-D-2, [C-11]DED) and (S)-N-[C-11]methyl-N-propargyl-1-phenylpropan-2-amine ([C-11]D-deprenyl, [C-11]DDE) were synthesised. One step N-alkylation with [C-11]MeI or [C-11]MeOTf was performed using the automated platform TRACERlab (R) FX-C Pro. The labelled products were obtained with (37 +/- 15)% (n=10) (end of synthesis, decay corrected from [C-11]MeI) radiochemical yields from [C-11]MeI after 38 +/- 3 min synthesis time. In all cases, radiochemical purity was over 99% when [C-11]MeOTf was used. This synthesis using a commercial platform makes these tracers more accessible for clinical research purposes. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：47 / 52

页数：6

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