Carbon-ion Radiotherapy for Oligometastatic Colorectal Cancer in the Liver or Lung

被引：7
作者：
Shiba, Shintaro [1 ,2 ]
Shibuya, Kei [1 ]
Okamoto, Masahiko [1 ]
Okano, Naoko [2 ]
Kubo, Nobuteru [1 ]
Kaminuma, Takuya [1 ]
Sato, Hiro [1 ]
Okazaki, Shohei [2 ]
Miyasaka, Yuhei [2 ]
Kawamura, Hidemasa [2 ]
Ohno, Tatsuya [1 ]
机构：
[1] Gunma Univ, Dept Radiat Oncol, Grad Sch Med, 3-39-22 Showa Machi, Maebashi, Gumma 3718511, Japan
[2] Gunma Univ, Heavy Ion Med Ctr, Gunma, Japan
来源：
ANTICANCER RESEARCH | 2021年 / 41卷 / 04期
关键词：
Carbon-ion radiotherapy; oligometastases; colorectal cancer; liver metastases; lung metastases;
D O I：
10.21873/anticanres.14967
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: We aimed to evaluate the clinical outcomes of oligometastatic colorectal cancer in the liver and lung treated with carbon-ion radiotherapy (C-ion RT). Patients and Methods: Nineteen consecutive patients with oligometastatic colorectal cancer in the liver or lung who received C-ion RT were analyzed. The doses of C-ion RT were 60.0 Gy [relative biological effectiveness (RBE)] in 4 fractions, 60.0 Gy (RBE) in 12 fractions, or 64.8 Gy (BRE) in 12 fractions. Results: The median follow-up duration was 19 months. There were 23 tumors in 19 patients. The 2-year overall survival and local control rates for the whole patient cohort were 100% and 67%, respectively. None of the patients developed grade 2 or higher acute or late toxicities. Conclusion: C-ion RT for oligometastatic colorectal cancer in liver and lung provides favorable clinical outcomes. These outcomes suggest C-ion RT is a treatment option for oligometastatic colorectal cancer in liver and lung.
引用
收藏
页码：1997 / 2005
页数：9
相关论文
共 35 条
  • [1] Dosimetric comparison of carbon ion radiotherapy and stereotactic body radiotherapy with photon beams for the treatment of hepatocellular carcinoma
    Abe, Takanori
    Saitoh, Jun-Ichi
    Kobayashi, Daijiro
    Shibuya, Kei
    Koyama, Yoshinori
    Shimada, Hirohumi
    Shirai, Katsuyuki
    Ohno, Tatsuya
    Nakano, Takashi
    [J]. RADIATION ONCOLOGY, 2015, 10
  • [2] Lung Metastases Treated With Stereotactic Ablative Radiation Therapy in Oligometastatic Colorectal Cancer Patients: Outcomes and Prognostic Factors After Long-Term Follow-Up
    Agolli, Linda
    Bracci, Stefano
    Nicosia, Luca
    Valeriani, Maurizio
    De Sanctis, Vitaliana
    Osti, Mattia Falchetto
    [J]. CLINICAL COLORECTAL CANCER, 2017, 16 (01) : 58 - 64
  • [3] [Anonymous], 2009, NCI COMMON TERMINOLO
  • [4] A DOSE-VOLUME ANALYSIS OF RADIATION PNEUMONITIS IN NON-SMALL CELL LUNG CANCER PATIENTS TREATED WITH STEREOTACTIC BODY RADIATION THERAPY
    Barriger, R. Bryan
    Forquer, Jeffrey A.
    Brabham, Jeffrey G.
    Andolino, David L.
    Shapiro, Ronald H.
    Henderson, Mark A.
    Johnstone, Peter A. S.
    Fakiris, Achilles J.
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 82 (01): : 457 - 462
  • [5] Stereotactic Ablative Radiotherapy (SABR) in inoperable oligometastatic disease from colorectal cancer: a safe and effective approach
    Comito, Tiziana
    Cozzi, Luca
    Clerici, Elena
    Campisi, Maria Concetta
    Liardo, Rocco Luca Emanuele
    Navarria, Pierina
    Ascolese, AnnaMaria
    Tozzi, Angelo
    Iftode, Cristina
    De Rose, Fiorenza
    Villa, Elisa
    Personeni, Nicola
    Rimassa, Lorenza
    Santoro, Armando
    Fogliata, Antonella
    Mancosu, Pietro
    Tomatis, Stefano
    Scorsetti, Marta
    [J]. BMC CANCER, 2014, 14
  • [6] Effect of high-dose stereotactic body radiation therapy on liver function in the treatment of primary and metastatic liver malignancies using the Child-Pugh score classification system
    Dyk, Pawel
    Weiner, Ashley
    Badiyan, Shahed
    Myerson, Robert
    Parikh, Parag
    Olsen, Jeffrey
    [J]. PRACTICAL RADIATION ONCOLOGY, 2015, 5 (03) : 176 - 182
  • [7] Ebara T, 2014, ANTICANCER RES, V34, P5099
  • [8] Hepatic and extrahepatic colorectal metastases: When resectable, their localization does not matter, but their total number has a prognostic effect
    Elias, D
    Liberale, G
    Vernerey, D
    Pocard, M
    Ducreux, M
    Boige, V
    Malka, D
    Pignon, JP
    Lasser, P
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2005, 12 (11) : 900 - 909
  • [9] Proton beam therapy for metastatic liver tumors
    Fukumitsu, Nobuyoshi
    Okumura, Toshiyuki
    Takizawa, Daichi
    Makishima, Hirokazu
    Numajiri, Haruko
    Murofushi, Keiko
    Ohnishi, Kayoko
    Mizumoto, Masashi
    Aihara, Teruhito
    Ishikawa, Hitoshi
    Tsuboi, Koji
    Sakurai, Hideyuki
    [J]. RADIOTHERAPY AND ONCOLOGY, 2015, 117 (02) : 322 - 327
  • [10] Single-dose radiosurgical treatment for hepatic metastases - therapeutic outcome of 138 treated lesions from a single institution
    Habermehl, Daniel
    Herfarth, Klaus K.
    Bermejo, Justo Lorenzo
    Hof, Holger
    Rieken, Stefan
    Kuhn, Sabine
    Welzel, Thomas
    Debus, Juergen
    Combs, Stephanie E.
    [J]. RADIATION ONCOLOGY, 2013, 8
1234