One-pot synthesis of γ-hydroxy-γ-oxaphosphonates using pentacovalent oxaphosphorane chemistry

被引：4

作者：

Hwang, Jae-Min ^{[2
]}

Islam, Tasneem ^{[1
]}

Jung, Kang-Yeoun ^{[2
]}

机构：

[1] Roosevelt Univ, Dept Biol Chem & Phys Sci, Chicago, IL 60173 USA

[2] Kangnung Wonju Natl Univ, Coll Engn, Dept Environm & Appl Chem, Kangnung 210702, South Korea

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 44期

关键词：

Phosphonates; Oxaphospholene; Enolate; Aldol product; ORGANIC-SYNTHESIS; PHOSPHONATES; ANALOGS; ROUTE;

D O I：

10.1016/j.tetlet.2009.08.059

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

P(V)-2,2,2-triethoxy-2,2-dihydro-5-methoxy-1,2 lambda(5)-oxaphospholene was synthesized as a new type of enolate which was hydrolyzed to give a series of phosphonates. In addition, aldol reaction of the oxaphospholene intermediate with several aldehydes as electrophiles under mild and neutral conditions produced phosphonate-containing aldol compounds through a two-step one-pot reaction. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6076 / 6078

页数：3

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