In vitro bioactivity and gentamicin release from glass-polymer-antibiotic composites

被引:0
作者
Ragel, CV [1 ]
Vallet-Regí, M [1 ]
机构
[1] Univ Complutense Madrid, Fac Farm, Dept Quim Inorgan & Bioinorgan, E-28040 Madrid, Spain
来源
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | 2000年 / 51卷 / 03期
关键词
glass-polymer composites; bioactive glass; apatite-like layer; gentamicin release; in vitro bioactivity;
D O I
10.1002/1097-4636(20000905)51:3<424::AID-JBM17>3.3.CO;2-5
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Composite materials have been prepared from bioactive glass powders in the SiO2-CaO-P2O5 system, a biodegradable polymer [poly(L-lactic acid) (PLA)], a biostable polymer [polymethylmethacrylate (PMMA)], and an antibiotic [gentamicin]. The purpose of such composites is to obtain implantable materials that are able to lead to bone growth and also can, at the most critical inflammation-infection step, release an antibiotic. X-ray diffraction, scanning electron microscopy, X-ray energy dispersive spectroscopy, and FTIR analyses after different soaking periods in SBF demonstrated the growth of an apatite-like layer on the composite surface. Therefore the bioactive glass-polymer-antibiotic combination used in this work does not inhibit the glass bioactivity. The release of gentamicin after a soaking of the materials in SBF was followed by UV-visible spectroscopy. A fast initial release during the first 10 h of soaking, followed by a controlled release of the drug was observed. (C) 2000 John Wiley & Sons, Inc.
引用
收藏
页码:424 / 429
页数:6
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