Plasma brain-derived neurotrophic factor in women with pelvic pain: a potential biomarker for endometriosis?

被引：25

作者：

Rocha, Ana L. ^{[1
]}

Vieira, Erica L. ^{[2
]}

Ferreira, Marcia C. ^{[1
]}

Maia, Laura M. ^{[1
]}

Teixeira, Antonio L. ^{[2
,3
]}

Reis, Fernando M. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Obstet & Gynecol, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Internal Med, Belo Horizonte, MG, Brazil

[3] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA

来源：

BIOMARKERS IN MEDICINE | 2017年 / 11卷 / 04期

关键词：

BDNF; benign ovarian tumor; biomarker; endometrioma; endometriosis; inflammation; laparoscopy; nerve fiber; pelvic pain; NERVE-FIBERS; EUTOPIC ENDOMETRIUM; INNERVATION; PERITONEAL; EXPRESSION; NODULES;

D O I：

10.2217/bmm-2016-0327

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To test whether plasma BDNF levels are useful to predict the presence of endometriosis in women with pelvic pain. Patients & methods: Prospective cross-sectional study including 67 consecutive women aged 24-49 years, scheduled for laparoscopy due to chronic pelvic pain. Preoperative plasma samples were assayed for BDNF using a commercial enzyme immunoassay. Results: Women with ovarian endometrioma had higher preoperative plasma BDNF (1063 +/- 157 pg/ml) compared with women with other benign ovarian tumors (537 +/- 131 pg/ml, F = 2.53; p = 0.02). However, plasma BDNF levels were not helpful to indicate the presence of peritoneal or deep infiltrating endometriosis. Plasma BDNF levels were positively correlated with the severity of pelvic pain (r = 0.489; p < 0.0001). Conclusion: Plasma BDNF might be a biomarker of ovarian endometrioma but not a useful diagnostic marker to detect other forms of endometriosis in women with painful symptoms.

引用

页码：313 / 317

页数：5