Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer

被引：33

作者：

Guo, Junli ^{[1
]}

Xie, Keping ^{[2
]}

Zheng, Shaojiang ^{[1
,2
]}

机构：

[1] Hainan Canc Hosp, Hainan Prov Key Lab Carcinogenesis & Intervent, Hainan Med Coll, Dept Pathol,Affiliated Hosp, 3 Xueyuan Rd, Haikou 571199, Hainan, Peoples R China

[2] Univ Texas MD Anderson Canc Ctr, Dept Gastroenterol Hepatol & Nutr, Houston, TX 77030 USA

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2016年 / 12卷 / 03期

基金：

美国国家卫生研究院;

关键词：

PanINs; Biomarker; Early Diagnosis; Therapeutic Intervention; TUMOR-SUPPRESSOR GENE; K-RAS MUTATIONS; DUCTAL ADENOCARCINOMA; STEM-CELLS; CYCLIN D1; MATRIX METALLOPROTEINASE-7; INTRADUCTAL NEOPLASIAS; DOWN-REGULATION; ONCOGENIC KRAS; EXPRESSION;

D O I：

10.7150/ijbs.14995

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lack of early detection and effective interventions is a major reason for the poor prognosis and dismal survival rates for pancreatic cancer. Pancreatic intraepithelial neoplasia (PanIN) is the most common precursor of invasive pancreatic ductal adenocarcinoma (PDAC). Each stage in the progression from PanIN to PDAC is well characterized by multiple significant genetic alterations affecting signaling pathways. Understanding the biological behavior and molecular alterations in the progression from PanIN to PDAC is crucial to the identification of noninvasive biomarkers for early detection and diagnosis and the development of preventive and therapeutic strategies for control of pancreatic cancer progression. This review focuses on molecular biomarkers of PanIN and their important roles in early detection and treatment of pancreatic cancer.

引用

页码：292 / 301

页数：10

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