Glycated Albumin, a Novel Biomarker for Short-Term Functional Outcomes in Acute Ischemic Stroke

被引：7

作者：

Kim, Yerim ^{[1
]}

Lee, Sang-Hwa ^{[2
]}

Kang, Min Kyoung ^{[3
]}

Kim, Tae Jung ^{[4
]}

Jeong, Han-Yeong ^{[5
]}

Lee, Eung-Joon ^{[4
]}

Bae, Jeonghoon ^{[4
]}

Jeon, Kipyoung ^{[4
]}

Nam, Ki-Woong ^{[6
]}

Yoon, Byung-Woo ^{[3
]}

机构：

[1] Hallym Univ, Kangdong Sacred Heart Hosp, Coll Med, Dept Neurol, Seoul 05355, South Korea

[2] Hallym Univ, Chuncheon Sacred Heart Hosp, Coll Med, Dept Neurol, Chunchon 24253, South Korea

[3] Eulji Univ, Coll Med, Uijeongbu Eulji Med Ctr, Dept Neurol, Uijeonbu Si 11759, South Korea

[4] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Neurol, Seoul 03080, South Korea

[5] Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Emergency Med Ctr,Dept Neurol, Seoul 03080, South Korea

[6] Seoul Natl Univ, Seoul Metropolitan Govt, Boramae Med Ctr, Dept Neurol, Seoul 03080, South Korea

来源：

BRAIN SCIENCES | 2021年 / 11卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

glycated albumin; glycated hemoglobin; brain ischemia; stroke; prognosis; biomarkers; blood glucose; DIABETIC-PATIENTS; GLYCOSYLATED HEMOGLOBIN; INFLAMMATION; ASSOCIATION; PREDICTS; LEVEL;

D O I：

10.3390/brainsci11030337

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: There is growing interest in the use of new biomarkers such as glycated albumin (GA), but data are limited in acute ischemic stroke. We explored the impact of GA on short-term functional outcomes as measured using the modified Rankin Scale (mRS) at 3 months compared to glycated hemoglobin (HbA1c). Methods: A total of 1163 AIS patients from two hospitals between 2016 and 2019 were included. Patients were divided into two groups according to GA levels (GA < 16% versus GA >= 16%). Results: A total of 518 patients (44.5%) were included in the GA >= 16% group. After adjusting for multiple covariates, the higher GA group (GA >= 16%) had a 1.4-fold risk of having unfavorable mRS (95% CI 1.02-1.847). However, HbA1c was not significantly associated with 3-month mRS. In addition, GA >= 16% was independently associated with unfavorable short-term outcomes only in patients without diabetes. Conclusions: In light of these results, GA level might be a novel prognostic biomarker compared to HbA1c for short-term stroke outcome. Although the impact of GA is undervalued in the current stroke guidelines, GA monitoring should be considered in addition to HbA1c monitoring.

引用

页码：1 / 12

页数：12

共 25 条

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