Gestational Age-Specific Cutoff Levels of TDx-FLM II for the Prediction of Neonatal Respiratory Distress Syndrome

被引：4

作者：

Bennasar, Mar ^{[2
]}

Figueras, Francesc ^{[2
]}

Palacio, Montse ^{[2
]}

Bellart, Jordi ^{[2
]}

Casals, Elena ^{[1
]}

Figueras, Josep ^{[3
]}

Coll, Oriol ^{[2
]}

Gratacos, Eduard ^{[2
]}

机构：

[1] Univ Barcelona, Hosp Clin, Inst Invest Biomed Augusto Pi & Sunyer, Dept Biochem, ES-08028 Barcelona, Spain

[2] Univ Barcelona, Hosp Clin, Inst Invest Biomed Augusto Pi & Sunyer, Maternal Fetal Med Dept, ES-08028 Barcelona, Spain

[3] Univ Barcelona, Hosp Clin, Inst Invest Biomed Augusto Pi & Sunyer, Inst Clin Ginecol Obstet & Neonatol,Dept Neonatol, ES-08028 Barcelona, Spain

来源：

FETAL DIAGNOSIS AND THERAPY | 2009年 / 25卷 / 04期

关键词：

Fetal lung maturity; Gestational age; Respiratory distress syndrome; TDx fetal lung maturity assay; FETAL LUNG MATURITY; TO-ALBUMIN RATIO; AMNIOTIC-FLUID; FLUORESCENCE POLARIZATION; ASSAY; PHOSPHATIDYLCHOLINE; PHOSPHOLIPIDS; ACCURACY; DISEASE;

D O I：

10.1159/000236152

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Aim: To construct a predictive model for respiratory distress syndrome (RDS) from gestational age (GA) at delivery and TDx-FLM II value. Methods: Pregnant women who underwent an amniocentesis in which TDx-FLM II was determined were included in the study. A model for the occurrence of RDS was constructed by means of a logistic regression procedure from TDx-FLM II values and GA at delivery. Results: The mean value of TDx-FLM II was 47.11 mg/g. The mean GA at delivery was 33.4 weeks. The incidence of RDS was 7.8% (18/231). The optimal cutoff of predicted risk for respiratory distress was found to be 8.8%, resulting in a sensitivity and specificity of 89 and 83%, respectively. Conclusions: The adjustment of the TDx-FLM II value for GA at delivery results in a significant improvement in the predictive capacity of the test for the occurrence of RDS. The use of GA-specific cutoff values may simplify clinical decisions. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：392 / 396

页数：5

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