Unique sodium-caged structure of a potent endothelin-1 inhibitor:: crystal structure of BQ123 sodium salt, cyclo(-D-Trp-D-Asp--Pro-D-Val-Leu-)•Na+

被引：2

作者：

Doi, M

Ishida, T

Katsuya, Y

Mezaki, Y

Sasaki, M

Terashima, A

Taniguchi, T

Hasegawa, H

Shiono, M

机构：

[1] Osaka Univ Pharmaceut Sci, Osaka 5691094, Japan

[2] Hyogo Prefectural Inst Ind Res, Kobe, Hyogo 6540037, Japan

[3] Hyogo Inst Aging Brain & Cognit Disorders, Himeji, Hyogo 6700981, Japan

[4] Kyushu Univ, Higashi Ku, Fukuoka 8128581, Japan

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 09期

关键词：

D O I：

10.1039/a909413j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The crystal structure of cyclo(D-Trp-D-Asp(-)-Pro-D-Val-Leu-). Na+, a potent endothelin-1 antagonist, showed four conformational isomers and two Na+-caged structures in pairs.

引用

页码：743 / 744

页数：2

共 2 条

[1] Caged and clustered structures of endothelin inhibitor BQ123, cyclo(-D-Trp-D-Asp--Pro-D-Val-Leu-)•Na+, forming five and six coordination bonds between sodium ions and peptides
Doi, M
Asano, A
Ishida, T
Katsuya, Y
Mezaki, Y
Sasaki, M
Terashima, A
Taniguchi, T
Hasegawa, H
Shiono, M
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2001, 57 : 628 - 634
[2] BQ-123, CYCLO(-D-TRP-D-ASP-PRO-D-VAL-LEU), IS A NONCOMPETITIVE ANTAGONIST OF THE ACTIONS OF ENDOTHELIN-1 IN SK-N-MC HUMAN NEUROBLASTOMA-CELLS
HILEY, CR
COWLEY, DJ
PELTON, JT
HARGREAVES, AC
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 184 (01) : 504 - 510

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