Two novel neo-clerodane diterpenoids from Scutellaria barbata

被引：33

作者：

Lee, Hanna ^{[1
]}

Kim, Yujin ^{[1
]}

Choi, Inho ^{[1
]}

Min, Byung Sun ^{[2
]}

Shim, Sang Hee ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Biotechnol, Gyongsan 712749, Gyeongbuk, South Korea

[2] Catholic Univ Daegu, Coll Pharm, Gyongsan 712702, Gyeongbuk, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 01期

关键词：

Neo-clerodane; Isolation; Structure determination; Cytotoxicity; CYTOTOXIC ACTIVITIES; ALKALOIDS; CONSTITUENTS;

D O I：

10.1016/j.bmcl.2009.10.116

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two novel neo-clerodane diterpenoids, barbatellarines A (1) and B (2), were isolated from the whole plants of Scutellaria barbata, along with the known compound scutebarbatine F (3). The chemical structures and relative stereochemistry of the isolated compounds were established by NMR (1D and 2D) and mass spectroscopic analyses. Compounds 2 and 3 were evaluated for in vitro cytotoxic activity against the HL-60 (human leukemia), MCF7 (human breast cancer), and LLC (Lewis lung carcinoma) cancer cell lines. Compound 2 exhibited weak cytotoxic activity against HL-60 cells, with an IC50 value of 41.4 mu M. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：288 / 290

页数：3

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