Pre-TCR/CD3 and TCR/CD3 complexes: decamers with differential signalling properties?

被引：0
作者：
Jacobs, H
机构：
来源：
IMMUNOLOGY TODAY | 1997年 / 18卷 / 12期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Currently, the favoured model for the structure of the T-cell receptor (TCR)/CD3 complex proposes a monovalent TCR alpha beta/CD3 gamma epsilon delta epsilon zeta zeta octameric complex. However, other biochemical, structure al and functional data point to a bivalent (TCR alpha beta)(2)/CD3 gamma epsilon delta epsilon zeta zeta decameric organization, which hits a favourable neutral transmembrane net charge within the complex. Here, Heinz Jacobs proposes it model for the organization of the pre-TCR and discusses its function in signal transduction.
引用
收藏
页码：565 / 569
页数：5
相关论文
共 65 条
  • [21] MEMBRANE-PROTEIN ASSOCIATION BY POTENTIAL INTRAMEMBRANE CHARGE PAIRS
    COSSON, P
    LANKFORD, SP
    BONIFACINO, JS
    KLAUSNER, RD
    [J]. NATURE, 1991, 351 (6325) : 414 - 416
  • [22] CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage
    Dave, VP
    Cao, ZS
    Browne, C
    Alarcon, B
    FernandezMiguel, G
    Lafaille, J
    delaHera, A
    Tonegawa, S
    Kappes, DJ
    [J]. EMBO JOURNAL, 1997, 16 (06) : 1360 - 1370
  • [23] TOPOLOGY AND AFFINITY OF T-CELL RECEPTOR MEDIATED RECOGNITION OF PEPTIDE MHC COMPLEXES
    DAVIS, MM
    CHIEN, YH
    [J]. CURRENT OPINION IN IMMUNOLOGY, 1993, 5 (01) : 45 - 49
  • [24] T-CELL ANTIGEN RECEPTOR GENES AND T-CELL RECOGNITION
    DAVIS, MM
    BJORKMAN, PJ
    [J]. NATURE, 1988, 334 (6181) : 395 - 402
  • [25] STRUCTURE OF THE T-CELL ANTIGEN RECEPTOR (TCR) - 2 CD3-EPSILON SUBUNITS IN A FUNCTIONAL TCR/CD3 COMPLEX
    DELAHERA, A
    MULLER, U
    OLSSON, C
    ISAAZ, S
    TUNNACLIFFE, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (01) : 7 - 17
  • [26] EVIDENCE FOR MULTIVALENT STRUCTURE OF T-CELL ANTIGEN RECEPTOR COMPLEX
    EXLEY, M
    WILEMAN, T
    MUELLER, B
    TERHORST, C
    [J]. MOLECULAR IMMUNOLOGY, 1995, 32 (11) : 829 - 839
  • [27] Structure and function of the T-cell receptor: Insights from x-ray crystallography
    Fields, BA
    Mariuzza, RA
    [J]. IMMUNOLOGY TODAY, 1996, 17 (07): : 330 - 336
  • [28] CRYSTAL-STRUCTURE OF THE V-ALPHA DOMAIN OF A T-CELL ANTIGEN RECEPTOR
    FIELDS, BA
    OBER, B
    MALCHIODI, EL
    LEBEDEVA, MI
    BRADEN, BC
    YSERN, X
    KIM, JK
    SHAO, XG
    WARD, ES
    MARIUZZA, RA
    [J]. SCIENCE, 1995, 270 (5243) : 1821 - 1824
  • [29] GEISLER C, 1992, J IMMUNOL, V148, P2437
  • [30] GEISLER C, 1990, J IMMUNOL, V145, P1761
1234567