Pathophysiology and pharmacological management of pulmonary and cardiovascular features of COVID-19

被引：7

作者：

Hamouche, Walid ^{[1
,2
]}

Bisserier, Malik ^{[1
]}

Brojakowska, Agnieszka ^{[1
]}

Eskandari, Abrisham ^{[1
]}

Fish, Kenneth ^{[1
]}

Goukassian, David A. ^{[1
]}

Hadri, Lahouaria ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Cardiovasc Res Ctr, Box 1030,1470 Madison Ave, New York, NY 10029 USA

[2] Brookdale Univ Hosp Med Ctr, Dept Internal Med, Brooklyn, NY USA

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2021年 / 153卷

关键词：

Physiopathology; COVID-19; Clinical features; Treatment; ANGIOTENSIN-CONVERTING ENZYME-2; SARS CORONAVIRUS; ACE2; RECEPTOR; DISEASE; PROTEIN; ENDOTHELIUM; EXPRESSION; INFECTION; INJURY;

D O I：

10.1016/j.yjmcc.2020.12.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The first confirmed case of novel Coronavirus Disease 2019 (COVID-19) in the United States was reported on January 20, 2020. As of November 24, 2020, close to 12.2 million cases of COVID-19 was confirmed in the US, with over 255,958 deaths. The rapid transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2), its unusual and divergent presentation has strengthened the status of COVID-19 as a major public health threat. In this review, we aim to 1- discuss the epidemiological data from various COVID-19 patient cohorts around the world and the USA as well the associated risk factors; 2- summarize the pathophysiology of SARSCoV-2 infection and the underlying molecular mechanisms for the respiratory and cardiovascular manifestations; 3- highlight the potential treatments and vaccines as well as current clinical trials for COVID-19.

引用

页码：72 / 85

页数：14

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