ABO blood group and ovarian reserve: a meta-analysis and systematic review

Ovarian reserve reflects a woman's fertility potential. The ABO blood group system is a very stable genetic marker. Although many recent studies have explored the relationship between ABO blood group and ovarian reserve, a consensus has not yet been reached. This paper is the first meta-analysis and systematic review of the relationship between ABO blood type and ovarian reserve. We analyzed seven cross-sectional studies evaluating follicle stimulating hormone (FSH) or anti-Mullerian hormone (AMH) levels in 55,113 participants to determine ovarian reserve. This study found no relationship between ABO blood type and ovarian reserve when FSH was used as an indicator of ovarian reserve (A vs non-A: OR=1.03, 95% CI: 0.96-1.11; B vs non-B: OR=0.98, 95% CI: 0.75-1.29; AB vs non-AB: OR=0.96, 95% CI: 0.71-1.30; O vs non-O: OR=1.03, 95% CI: 0.74-1.43). There was also no relationship between ABO blood type and ovarian reserve when AMH was used as an indicator (A vs non-A: OR=0.89, 95% CI: 0.76-1.03; B vs non-B: OR=1.02, 95% CI: 0.80-1.30; AB vs non-AB: OR=1.14, 95% CI: 0.80-1.64, O vs non-O: OR=1.07, 95% CI: 0.86-1.34). Overall, the current study found no relationship between ABO blood group and ovarian reserve. However, additional rigorous, high-quality and multi-indicator studies with large sample sizes are required for further verification.