Biocompatibility study on Ni-free Ti-based and Zr-based bulk metallic glasses

被引：40

作者：

Li, T. H. ^{[1
]}

Wong, P. C. ^{[3
]}

Chang, S. F. ^{[2
]}

Tsai, P. H. ^{[1
]}

Jang, J. S. C. ^{[1
,2
]}

Huang, J. C. ^{[4
]}

机构：

[1] Natl Cent Univ, Inst Mat Sci & Engn, Taoyuan, Taiwan

[2] Natl Cent Univ, Dept Mech Engn, Taoyuan, Taiwan

[3] Natl Yang Ming Univ, Dept Biomed Engn, Taipei, Taiwan

[4] Natl Sun Yat Sen Univ, Dept Mat & Optoelect Sci, Kaohsiung, Taiwan

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 75卷

关键词：

Bulk metallic glass; L929 murine fibroblast cell line; MTT; Biocompatibility; ALLOYS;

D O I：

10.1016/j.msec.2017.02.006

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Safety and reliability are crucial issues for medical instruments and implants. In the past few decays, bulk metallic glasses (BMGs) have drawn attentions due to their superior mechanical properties, good corrosion resistance, antibacterial and good biocompatibility. However, most Zr-based and Ti-based BMGs contain Ni as an important element which is prone to human allergy problem. In this study, the Ni-free Ti-based and Zr-based BMGs, Ti40Zr10Cu36Pd14, and Zr48Cu36Al8Ag8, were selected for systematical evaluation of their biocompatibility. Several biocompatibility tests, co-cultural with L929 murine fibroblast cell line, were carried out on these two BMGs, as well as the comparison samples of Ti6Al4V and pure Cu. The results in terms of cellular adhesion, cytotoxidty, and metallic ion release affection reveal that the Ti(40)Zt(10)Cu(36)Pd(14) BMG and Ti6A14V exhibit the optimum biocompatibility; cells still being attached on the petri dish with good adhesion and exhibiting the spindle shape after direct contact test. Furthermore, the Ti(40)Zt(10)Cu(36)Pd(14) BMG showed very low Cu ion release level, in agreement with the MIT results. Based on the current findings, it is believed that Ni-free Ti-based BMG can act as an ideal candidate for medical implant. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：1 / 6

页数：6

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