The Role of Post-Resuscitation Electrocardiogram in Patients With ST- Segment Changes in the Immediate Post-Cardiac Arrest Period

OBJECTIVES The authors aimed to evaluate the role of post-resuscitation electrocardiogram (ECG) in patients showing significant ST-segment changes on the initial ECG and to provide useful diagnostic indicators for physicians to determine in which out-of-hospital cardiac arrest (OHCA) patients brain computed tomography (CT) should be performed before emergency coronary angiography. BACKGROUND The usefulness of immediate brain CT and ECG for all resuscitated patients with nontraumatic OHCA remains controversial. METHODS Between January 2010 and December 2014, 1,088 consecutive adult nontraumatic patients with return of spontaneous circulation who visited the emergency department of 3 tertiary care hospitals were enrolled. After excluding 245 patients with obvious extracardiac causes, 200 patients were finally included. RESULTS The patients were categorized into 2 groups: those with ST-segment changes with spontaneous subarachnoid hemorrhage (SAH) (n = 50) and those with OHCA of suspected cardiac origin group (n = 150). The combination of 4 ECG characteristics including narrow QRS (< 120 ms), atrial fibrillation, prolonged QTc interval (>= 460 ms), and >= 4 ST-segment depressions had a 66.0% sensitivity, 80.0% specificity, 52.4% positive predictive value, and 87.6% negative predictive value for predicting SAH. The area under the receiver-operating characteristic curves in the post-resuscitation ECG findings was 0.816 for SAH. CONCLUSIONS SAH was observed in a substantial number of OHCA survivors (25.0%) with significant ST-segment changes on post-resuscitation ECG. Resuscitated patients with narrow QRS complex and any 2 ECG findings of atrial fibrillation, QTc interval prolongation, or >= 4 ST-segment depressions may help identify patients who need brain CT as the next diagnostic work-up. (J Am Coll Cardiol Intv 2017; 10: 451-9) (C)2017 by the American College of Cardiology Foundation.