The Diversification of Cell Death and Immunity: Memento Mori

被引：134

作者：

Legrand, Arnaud J. ^{[1
]}

Konstantinou, Maria ^{[1
]}

Goode, Emily F. ^{[1
]}

Meier, Pascal ^{[1
]}

机构：

[1] Inst Canc Res, Breast Canc Now Toby Robins Res Ctr, London SW3 6JB, England

来源：

MOLECULAR CELL | 2019年 / 76卷 / 02期

关键词：

CYTOCHROME-C RELEASE; PROGRAMMED NECROSIS; NLRP3; INFLAMMASOME; INTERACTING PROTEIN; APOPTOTIC CELLS; DENDRITIC CELLS; GASDERMIN-D; CANCER; ACTIVATION; NECROPTOSIS;

D O I：

10.1016/j.molcel.2019.09.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Why do cells have so many ways to die? Why does "cellular suicide'' exist at all? In the war against pathogens and rogue cells, organisms developed cellular suicide as a last resort. Fighting an evolutionary arms race, cell death pathways have adapted and multiplied to cover the complexity of the foes the immune system faces. In this review, we discuss the different types of cell death, the underlying signaling events, and their unequal ability to trigger an immune response. We also comment on how to use our knowledge of cell death signaling to improve the efficacy of cancer treatment. We argue that cell death is integral to the immune response and acts as a beacon, a second messenger, that guides both immune system and tissue micro-environment to ensure tissue repair and homeostasis. Memento mori-"remember you must die''-as failure to do so opens the way to chronic infection and cancer.

引用

页码：232 / 242

页数：11

共 115 条

[1] Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity [J].

Aaes, Tania Love ;

Kaczmarek, Agnieszka ;

Delvaeye, Tinneke ;

De Craene, Bram ;

De Koker, Stefaan ;

Heyndrickx, Liesbeth ;

Delrue, Iris ;

Taminau, Joachim ;

Wiernicki, Bartosz ;

De Groote, Philippe ;

Garg, Abhishek D. ;

Leybaert, Luc ;

Grooten, Johan ;

Bertrand, Mathieu J. M. ;

Agostinis, Patrizia ;

Berx, Geert ;

Declercq, Wim ;

Vandenabeele, Peter ;

Krysko, Dmitri V. .

CELL REPORTS, 2016, 15 (02) :274-287

[2] Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases [J].

Akdis, Mubeccel ;

Aab, Alar ;

Altunbulakli, Can ;

Azkur, Kursat ;

Costa, Rita A. ;

Crameri, Reto ;

Duan, Su ;

Eiwegger, Thomas ;

Eljaszewicz, Andrzej ;

Ferstl, Ruth ;

Frei, Remo ;

Garbani, Mattia ;

Globinska, Anna ;

Hess, Lena ;

Huitema, Carly ;

Kubo, Terufumi ;

Komlosi, Zsolt ;

Konieczna, Patricia ;

Kovacs, Nora ;

Kucuksezer, Umut C. ;

Meyer, Norbert ;

Morita, Hideaki ;

Olzhausen, Judith ;

O'Mahony, Liam ;

Pezer, Marija ;

Prati, Moira ;

Rebane, Ana ;

Rhyner, Claudio ;

Rinaldi, Arturo ;

Sokolowska, Milena ;

Stanic, Barbara ;

Sugita, Kazunari ;

Treis, Angela ;

van de Veen, Willem ;

Wanke, Kerstin ;

Wawrzyniak, Marcin ;

Wawrzyniak, Paulina ;

Wirz, Oliver F. ;

Zakzuk, Josefina Sierra ;

Akdis, Cezmi A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 138 (04) :984-1010

[3] The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis [J].

Alvarez-Diaz, Silvia ;

Dillon, Christopher P. ;

Lalaoui, Najoua ;

Tanzer, Maria C. ;

Rodriguez, Diego A. ;

Lin, Ann ;

Lebois, Marion ;

Hakem, Razq ;

Josefsson, Emma C. ;

O'Reilly, Lorraine A. ;

Silke, John ;

Alexander, Warren S. ;

Green, Douglas R. ;

Strasser, Andreas .

IMMUNITY, 2016, 45 (03) :513-526

[4] Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma [J].

Andtbacka, Robert H. I. ;

Kaufman, Howard L. ;

Collichio, Frances ;

Amatruda, Thomas ;

Senzer, Neil ;

Chesney, Jason ;

Delman, Keith A. ;

Spitler, Lynn E. ;

Puzanov, Igor ;

Agarwala, Sanjiv S. ;

Milhem, Mohammed ;

Cranmer, Lee ;

Curti, Brendan ;

Lewis, Karl ;

Ross, Merrick ;

Guthrie, Troy ;

Linette, Gerald P. ;

Daniels, Gregory A. ;

Harrington, Kevin ;

Middleton, Mark R. ;

Miller, Wilson H., Jr. ;

Zager, Jonathan S. ;

Ye, Yining ;

Yao, Bin ;

Li, Ai ;

Doleman, Susan ;

VanderWalde, Ari ;

Gansert, Jennifer ;

Coffin, Robert S. .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (25) :2780-U98

[5] Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion [J].

Angeli, Jose Pedro Friedmann ;

Krysko, Dmitri, V ;

Conrad, Marcus .

NATURE REVIEWS CANCER, 2019, 19 (07) :405-414

[6] Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer [J].

Annibaldi, Alessandro ;

Meier, Pascal .

TRENDS IN MOLECULAR MEDICINE, 2018, 24 (01) :49-65

[7] Phagocytosis of apoptotic cells in homeostasis [J].

Arandjelovic, Sanja ;

Ravichandran, Kodi S. .

NATURE IMMUNOLOGY, 2015, 16 (09) :907-917

[8] SUMO-mediated regulation of NLRP3 modulates inflammasome activity [J].

Barry, Rachael ;

John, Sidonie Wicky ;

Liccardi, Gianmaria ;

Tenev, Tencho ;

Jaco, Isabel ;

Chen, Chih-Hong ;

Choi, Justin ;

Kasperkiewicz, Paulina ;

Fernandes-Alnemri, Teresa ;

Alnemri, Emad ;

Drag, Marcin ;

Chen, Yuan ;

Meier, Pascal .

NATURE COMMUNICATIONS, 2018, 9

[9] Combinatorial strategies for the induction of immunogenic cell death [J].

Bezu, Lucillia ;

Gomes-de-Silva, Ligia C. ;

Dewitte, Heleen ;

Breckpot, Karine ;

Fucikova, Jitka ;

Spisek, Radek ;

Galluzzi, Lorenzo ;

Kepp, Oliver ;

Kroemer, Guido .

FRONTIERS IN IMMUNOLOGY, 2015, 6

[10] Intracellular Nucleic Acid Sensing Triggers Necroptosis through Synergistic Type I IFN and TNF Signaling [J].

Brault, Michelle ;

Olsen, Tayla M. ;

Martinez, Jennifer ;

Stetson, Daniel B. ;

Oberst, Andrew .

JOURNAL OF IMMUNOLOGY, 2018, 200 (08) :2748-2756

← 1 2 3 4 5 6 7 8 9 10 →